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Antioxidants

Rasagiline

Rasagiline is a synthetic compound that is used to treat the symptoms of Parkinson’s disease. It is a relatively new drug and was approved by the Federal Drug Administration (FDA) on May 16, 2006. Rasagiline is considered one of the primary monoamine oxidase inhibitors.

History

Rasagiline was developed in the very early 2000s by Teva Pharmaceutical Industries Ltd. under the direction of Professor Moussa Youdim. Youdim first presented the drug to the FDA in 2004. In 2006, after extensive research was done to prove the safety of the drug, rasagiline was approved. It is now one of the most common Parkinson’s medications in the world.

Usage

Rasagiline is used solely for treating the symptoms and slowing the progression of Parkinson’s disease. The symptoms of Parkinson’s disease occur when dopamine, a neurotransmitter that helps with cognition and motor skills, is not able to reach the brain. There are several factors and/or causes that can block dopamine. One of these causes is the presence of monoamine oxidase enzymes in the brain.

Every person’s brain has a certain amount of monoamine oxidase A and monoamine oxidase B (often shortened to MAO-A and MAO-B). One of the adverse effects of these enzymes is that they can metabolize (breakdown) dopamine before it can do the person any good. The main culprit is MAO-B. Although MAO-A does metabolize dopamine, it also metabolizes serotonin and several other chemicals and enzymes and, therefore, cannot do as much damage to one single substance. MAO-B on the other hand, only metabolizes dopamine. Also, MAO-B is always much more prevalent than MAO-A.
Side Effects of Rasagiline
Some of the common drugs that treat Parkinson’s disease are called monoamine oxidase inhibitors. MAO inhibitors stop the production of the MAO enzymes, particularly the MAO-B, and, therefore, allow dopamine to function properly. The most common MAO inhibitor is rasagiline.

Although rasagiline is prescribed for patients at all stages of Parkinson’s disease, it is most commonly given to patients at the early stage. Although the drug’s long term effects have not yet been established, it has been proven to help slow the progression of the disease. Rasagiline can also be prescribed solely to help control the symptoms of Parkinson’s disease.

Recommended Dosage

Rasagiline is often taken in conjunction with other medications; the most common of which is levodopa. When rasagiline is combined with another drug, often referred to as adjunctive therapy, it is recommended to only take 0.5 mg per day. If the drug is taken on its own, often called monotherapy, the patient can take up to 1 mg per day. In some cases, 1 mg per day is prescribed for adjunctive therapy. However, a patient should never exceed more than 1 mg per day. The drug is always taken orally.

Rasagiline can be taken on an empty stomach. Never “double dose” because the drug can be fatal if taken in large amounts. Signs of rasagiline overdose include extreme irritability, sweating, changes in heart rate and/or breathing patterns, convulsions, and even seizures. If an overdose is suspected, medical help should be sought at once. If necessary, call a poison control center.

There is absolutely no risk of developing a dependency on this drug.

Legal Status

Rasagiline has been approved by the FDA but is available only with a prescription. Rasagiline is not illegal in any other country and, in Canada for example, is sometimes available without a prescription. The drug is very popular in Europe partly because it was promoted by the drug company Lundbeck.

Availability and Cost

Azilect

Rasagiline is commonly referred to by its brand name Azilect. In fact, when Youdim presented his drug to the FDA, he presented it as Azilect. In the USA, Azilect is available by prescription only. One month’s supply usually costs around $250. Azilect ordered online, from Canadian pharmacies for example, is usually slightly cheaper. In cases like this, one month’s supply usually costs anywhere from $150 to $200 (USD). So far, Azilect is the only brand name version of the rasagiline drug.

Generic

There are several, cheaper, generic brands of the drug. Generics are usually just called rasagiline (similar to the fact that generic Tussin is called Tussin while the brand name is Robitussin). Both the generic and the brand name forms of the drug should be covered by most medical insurances. Rasagiline/Azilect is always taken in tablet form.

Adverse Effects

Although rasagiline has been proven effective, it can cause some very serious side effects. Patients should not drive until they are certain they are reacting well to the drug. Also, most monoamine oxidase inhibitors do not react well with other pharmaceuticals and/or over-the-counter medications (see below). Be sure to speak with a qualified professional before beginning use of this drug.

Mild side effects

Some of the more mild, and common, side effects of rasagiline include headache, drowsiness, joint pain, and dizziness. Some people experience an allergic reaction, similar to a food allergy, that can cause hives, airway constriction, and swelling of the throat, tongue, or eyes. Rasagiline may also cause intestinal problems such as vomiting, diarrhea, or constipation; it may also cause mild vertigo, hallucinations, and sensory impairment. Ever since rasagiline was presented to the FDA, there has been a concern that the drug may cause skin cancer. However, it has been decided that, although the risk is present, it is not, by any means, serious.

Severe Side Effects

Some of the more severe, but thankfully rare, side effects of rasagiline include changes in heart rate, lung fibroses, emphysema, and, possibly, manic and/or paranoid reactions. There is a slight chance that patients taking rasagiline may develop bacterial or viral infections. However, these infections can usually be cleared up with common antibiotics. In some extremely rare cases, rasagiline has caused acute kidney failure, retinal hemorrhage, and jaundice.

Rasagiline may cause sexual and/or reproductive problems. Men may experience abnormal ejaculation, epididymitis (inflammation and/or swelling of the epididymis), and, rarely, pariapism (persistent erection without sexual desire). Women sometimes experience vaginal hemorrhage, loss of sexual desire, and amenorrhea (absence or severe disruption of the normal menstrual cycle).

Drug Interactions

Over-the-counter medications

Rasagiline does not react well with guaifenesin and dextromethorphan, two common ingredients in over-the-counter cough medicines. The combination of these drugs may cause temporary psychosis. A similar reaction can be caused by the combination of rasagiline and most common allergy medications.
Benefits of Rasagilin
Also, rasagiline should never be mixed with painkillers such as meperidine and acetaminophen (Tylenol). Rasagiline mixed with these drugs can cause fatal reactions.

Natural supplements

Although it is highly unlikely, rasagiline may not react well with vitamins, herbs, and other natural dietary supplements. A patient should tell a qualified professional about all supplements and medications he or she is taking regardless of whether they are natural or chemical.

Antidepressants

Rasagiline does not react well with any antidepressant medications. However, the main ones to avoid are duloxetine (Cymbalta), desipramine (Norpramin), fluoxetine (Prozac), and amitriptyline (Vanatrip).

Other Information

Diet Restrictions

When rasagiline was first approved by the FDA, it was thought that severe diet restrictions were necessary to help the drug work properly. It used to be that patients taking the drug would have to avoid the amino acid tyramine. Tyramine acts as a releasing agent for dopamine and it was thought that, since rasagiline inhibits the development of the MAO enzymes, it might also cause a buildup of tyramine which can also have adverse effects.

Tyramine occurs naturally in many foods including cheese, avocados, aged meats, soy products, pineapples, raspberries, peanuts, Brazil nuts, walnuts, yeast, and chocolate. Tyramine is also present in unpasteurized beers and red wines.

In the early days of rasagiline, patients would have to go on a strict diet to avoid ingesting tyramine. However, in 2009, the FDA decided that tyramine restrictions were only necessary for patients with extreme sensitivity to the amino acid. However, some medical doctors still recommend that the diet be followed simply as a precaution.

When Not To Take It

Rasagiline should never be taken by those who have or have ever had any kind of kidney or liver disease. The drug should not be taken by people who suffer from a pheochromocytoma (a small neuroendocrine tumor that affects the adrenal glands).

The drug is not recommended for children. It is not yet known if rasagiline is safe for pregnant mothers. The drug is not, however, recommended for women who are nursing because it may slow the production of breast milk.

A person taking rasagiline should cease using it at least 2 weeks before undergoing any form of elective surgery or even simple outpatient procedures or dental operations.

Although use of the drug in these cases is not forbidden, caution should be used when rasagiline is taken by patients with high blood pressure. The patient and his or her health care provider will need to constantly monitor the effects of the drug. Extremely high blood pressure that develops after the patient has begun use of the drug may be a sign of serious drug interactions. If this occurs, use of rasagiline should be stopped and the patient should seek medical help immediately.

Resources

MedicineNet.Com
MayoClinic.Com

Vitamins

Tocophersolan

Overview

Tocofersolan is a synthetic form of vitamin E that is also water soluble. Natural forms of Vitamin E are fat soluble instead of water soluble. Chemically, tocofersolan, is a polyethylene glycol. The product is derived from an alpha-tocopehrol. The synthetic form of vitamin E, Tocofersolan, is available for people who cannot absorb fats as result of a particular disease. Some of these diseases include cholestatic liver and short bowel syndrome. Individuals who possess a healthy, normal diet typically do not need a vitamin E supplement. However, in some instances the supplement is necessary.

This form of vitamin E supplement was introduced in July of 2009 under the name, Vedrop. The 50 milligram per milliliter solution was introduced to alleviate vitamin E deficiency in infants who suffer from malabsorption. Alternatively, it was also for patients suffering from congenital or chronic cholestasis. Most of these conditions originate from birth. Some conditions begin in adolescence when the teenager is between 16 and 18 years old. Age groups may vary depending upon the region.
Tocophersolan Safety
When physicians refer to vitamin E, they are describing a family of eight antioxidants. There are four tocopherols and four tocotrienols that comprise the family. Each of the groups contains an alpha, beta, gamma, and delta version of the antioxidant. Alpha-tocopherol is the most common form of vitamin E found in the body and thus, is the most widely researched discussed. When smoke or pollutants enter the body and form free radicals, alpha-tocopherals are the primary antioxidant that intercepts the free radicals to avoid damage in the body.

Problems in Nervous System

Vitamin E deficiencies can cause problems in the nervous system. These problems manifests as numbness, loss of balance, and tingling. Vitamin E is an antioxidant that protects the body’s cells from damage. Because tocofersolan is an antioxidant, this water soluble version of vitamin E is often found in cosmetics or pharmaceuticals.

Alpha-tocopherol protects the cellular membrane from oxidation. The antioxidant accomplishes this goal through a “lipid peroxidation chain reaction.” This process removes damaging free radicals and prevents further oxidation that may damage the cells. After this process is complete, antioxidants, retinol, ascorbate, or ubiquinol, may transform the alpha-tocopheroxyl radicals back into their oxidized state.

Scientists have not proven why vitamin E is vitally important in a person’s diets. Some speculate that its importance is related to its healing antioxidant properties. Some research also suggests that vitamin E functions as a signaling molecule as opposed to playing a role in antioxidant metabolism. However, this has not been proven conclusively.

Different Forms

Vitamin E comes in several different forms. Each form has the same basic function with a few unique qualities. Gamma-tocopherol is an example of a nucleophile that interacts with “electrophilic mutagens” in the body. Most research conducted is related to alpha-tocopherols. Much of the research relates to the heart disease and the efficacy of vitamin E in preventing heart disease. The studies are not conclusive.

According to a 2007 study, none of the research could conclusively prove the effects of vitamin E. Additionally, tocopherols are studied more than tocotrienols in relation to vitamin E. Although, this is one of the lesser known versions of vitamin E, more research is being conducted in order to prove the efficacy of this form in the daily diet.

Experts are suggesting however, that the main role of tocotrienols is to protect the neurons from damage and to reduce cholesterol. This version of vitamin E is also thought to protect against strokes and brain damage that is associated with strokes. More studies must be conducted to prove these findings conclusively.

Recommended Daily Allowances (RDA)

Physicians instruct individuals to take no more than 400 units of vitamin E per day to avoid unpleasant side effects. The Recommended Daily Allowances are determined by Dietary Reference Intakes (DRIs) and the Food and Nutrition Board (FNB). The Recommended Daily Allowances provided below refer to alpha-tocopherol and not to gamma and delta-tocopherol. For reference purposes: 1 milligram of alpha-tocopherol is equal to 2.22 IU and 1 IU of alpha-tocopherol is equal to 0.45 milligrams of the synthetic form of vitamin E. The Recommended Daily Allowances are listed below:

Birth to 6 months

Males and Females: 4 mg or 6 IU

7 to 12 months

Males and Females: 5 mg or 7.5 IU

1 to 3 years

Males and Females: 6 mg or 9 IU

4 to 8 years

Males and Females: 7 mg or 10.4 IU

9 to 13 years

Males and Females: 11 mg or 16.4 IU

14 years and older

Males and Females: 15 mg and 22.4 IU

Pregnant Females: 15 mg and 22.4 IU

Lactation: 19 mg and 28.4 IU

Take vitamin E as instructed by your physician or as instructed on the label. Most forms of vitamin E are ingested orally. However, there are topical forms of vitamin E as well. If your experience tingling or numbing in the feet, then you may have a serious medical problem and you should seek the advisement of a physician.

Sources of Tocofersolan

Although, tocofersolan refers to water soluble synthetic forms of vitamin E, food sources that contain vitamin E sources are listed below for the sake of knowledge. The foods listed below have very high levels of vitamin E:

  • Asparagus
  • Avocado
  • Egg
  • Milk
  • Nuts (Almonds, Hazelnuts)
  • Seeds
  • Spinach
  • Wheat Germ
  • Whole Grain Foods
  • Unheated Vegetable Oils

Other sources include:

  • Sunflower seeds: 1 ounce contains 7.4 mg of vitamin E which equates to 40 percent of the Daily Value (DV) of vitamin E.
  • Wheat germ oil: 1 tablespoon contains 20.3 mg of vitamin E which equates to 100 percent of the Daily Value (DV) of vitamin E.
  • Sunflower oil: 1 ounce contains 6 mg of vitamin E which equates to 30 percent of the Daily Value (DV) of vitamin E.
  • Safflower oil: 1 tablespoon contains 4.6 mg of vitamin E which equates to 25 percent of the Daily Value (DV) of vitamin E.
  • Hazelnuts: 1 ounce contains 4.3 mg of vitamin E which equates to 22 percent of the Daily Value (DV) of vitamin E.
  • Peanut Butter: 2 tablespoons contains 2.9 mg of vitamin E which equates to 15 percent of the Daily Value (DV) of vitamin E.
  • Spinach: 0.5 cup contains 1.9 mg of vitamin E which equates to 10 percent of the Daily Value (DV) of vitamin E.
  • Broccoli: 0.5 ounce contains 1.2 mg of vitamin E which equates to 6 percent of the Daily Value (DV) of vitamin E.
  • Kiwi: 1 medium kiwi contains 1.1 mg of vitamin E which equates to 6 percent of the Daily Value (DV) of vitamin E.
  • Tomato: 1 medium contains 0.8 mg of vitamin E which equates to 4 percent of the Daily Value (DV) of vitamin E.
  • Mango: 0.5 cup contains 0.9 mg of vitamin E which equates to 5 percent of the Daily Value (DV) of vitamin E.

Health Benefits

Vitamin E may prove to be effective in treating or preventing any of the following health conditions:

  • Cystic Fibrosis
  • Thalassemia
  • Sickle Cell Anemia
  • Disease of the Retina of the Eye in Premature Infants
  • Blockage of Normal Bile Flow
  • Hemorrhage into a Part of the Brain of a Newborn Infant
  • Abnormal Development of Bronchopulmonary Tissue in Newborn
  • Anemia in Low Birthweight Infants
  • Abetalipoproteinemia

Other studies have shown that selenium taken with vitamin E may reduce the risk of prostate cancer. Experts speculate that the disease may be reduced by as much as 30 percent. Other studies have shown that Vitamin E did not prevent prostate cancer. Thirty-five thousand men participated in the study. The studies are inconclusive and further research must be conducted to prove these findings.

Ailments from Vitamin E (tocofersolan) Deficiencies

Vitamin E deficiencies are rare. Symptoms rarely manifest in people who have not obtained vitamin E from their diets. Premature infants may suffer from a deficiency in vitamin E. These deficiencies may promote infections of the retina and other parts of the body.

Those individuals who possess absorption problems related to fat are more likely to develop a deficiency in vitamin E than those who can absorb fat through food. People who possess fat-malabsorption problems have difficulties because the digestive tract requires fat to absorb natural fat-soluble vitamin E. Tocofersolan was developed in order aid people with fat absorption disorders. Tocofersolan should be used in the same manner that vitamin E would be used in the body.

People who have symptoms of deficiency may experience:

  • Peripheral neuropathy
  • Ataxia
  • Skeletal Myopathy
  • Retinopathy
  • Immune Response Impairment

Crohn’s disease, Cystic fibrosis, and other Liver Conditions

People with Crohn’s disease, cystic fibrosis, or who have problems with their livers secreting bile may require a water soluble form of vitamin E, tocofersolan. People with bile problems may experience chronic diarrhea or stools that contain grease.

Abetalipoproteinemia

People with abetalipoproteinemia also have a problem absorbing fat from natural foods. These individuals may also require a water soluble supplement. Most of these patients require as much as 100 mg per day of this substance. This rare disorder is a result of a genetic inheritance and cannot be prevented. Abetalipoproteinemia causes muscle weakness, poor nerve impulse transmissions, and retinal degradation. In some instances, the retinal degradation may lead to blindness.
Tocophersolan Information

Ataxia

Ataxia is another rare disorder that is the result of a defective gene. This particular disorder is a result of the absence of the transfer protein, alpha-tocopherol. People with this disease lose their ability to walk or develop nerve damage.

Negative effects of Vitamin E

Congenital heart defects

Some studies have found that vitamin E was recommended for pregnant mothers. However, one study conducted in the Netherlands suggested that high quantities of vitamin E supplements during pregnancy may contribute to congenital heart defects. The National Health Service in the United Kingdom suggests that pregnant women should not take supplemental vitamin E tablets. More studies should be conducted in order to determine the efficacy of this particular supplement.

Vitamin E, strokes and heart attacks

While studies have shown in that vitamin E may have some benefits for stroke victims, new studies indicate that vitamin E supplements may actually increase the risk of a stroke. A Finnish group of scientists found this to be true in their particular study. The study was published by The Alpha-Tocopherol Beta-Carotene Cancer Prevention Study Group. In a 2005 study conducted by the Journal of American Medical Association, vitamin E supplements were shown to increase the risk of heart failure. Nearly 7000 people participated in this particular trial. The findings are inconclusive and more studies should be conducted to prove this conclusively.

Another study published in the Stroke Journal in 2005 showed that tocotrienol administered to hypertensive rats did protect against strokes. This form of vitamin E was administered orally to the rats. The supplement also showed improvements in neurodegeneration. Tocopherols were also studied. However, this particular form of vitamin E was only found effective at higher concentrates.

Additional Study Conclusions

Other studies conducted by Wayne State University and Ohio State University Medical Center showed that tocotrienol offered health benefits to various organs in the body. Previous studies concluded that tocotrienols did not travel effectively as a synthetic supplement in the blood stream. This is because the transfer protein is less attracted to tocotrienols than tocopherols. This study was also conducted in 2005. People with fat malabsorption problems will be more likely to benefit from tocofersolan, which is water based. However, this synthetic form focuses primarily on the alpha-tocopherol aspect of vitamin E.

By contrast, in a small study of men who had previously undergone coronary artery bypass surgery, the studies found that these men saw a reduction in the instances of atherosclerosis. Physicians measured this by using an angiography. These men consumed 100 IU per day of alpha-tocopherol to achieve these results. While the vitamin did alleviate some of the symptoms associated with heart disease, vitamin E alone did not reduce the number of total deaths from heart disease. However, the vitamin did reduce the number of non-fatal heart attacks by 77 percent. This trial took place in Great Britain.

Vitamin E and Cancer

Studies are being conducted to prove the efficacy of vitamin E in various types of cancers. Experts speculate that many cancers result from damage caused by free radicals. Vitamin E is an antioxidant that assists in the protection against cancer causing free radicals. Nitrosamines are also known carcinogens that are formed in the stomach. Vitamin E may also fight or block these carcinogens. Trials, associated with vitamin E and cancer, have not provided any conclusive results to positively and concretely solidify these results. Most of the studies involved human subjects.

Breast cancer studies have also been conducted. One such study involved over 83,000 women to study the effects of vitamin E for 14 years. This study showed that vitamin E reduced the chance of breast cancer by 43 percent in those patients who consumed the highest amount of vitamin E. Women with the family history of breast cancer enjoyed the greatest benefits. Women with no family history only experienced a 16 percent reduction in the risk for breast cancer.

Tocotrienols have been cited in research studies as possessing cancer eliminating effects. Most of these studies were conducted in conjunction with breast cancer. University of Louisiana at Monroe demonstrated that statins and tocotrienols were effective in treating breast cancer in women. This form of vitamin E killed cancer cells while avoiding myotoxicity. Gamma-tocotrienol has been proven to be most effective in killing cancer cells. This phenomenon of killing cancer cells was not only proven effective in breast cancer, but also prostate cancer and other melanomas.

Peyronie’s Disease

Some urologists may prescribe vitamin E for Peyronie’s disease. This disease describes the treatment for males who possess abnormal curvature in their penises due to inflammation. While the studies are not conclusive, scientists are constantly researching to determine the benefits of vitamin in this disease.

Neuromuscular Problems

Vitamin E deficiencies have been known to contribute to neurological problems. Some of the neuromuscular problems include spincerbellar ataxia and myopathies. Anemia may also result from vitamin E deficiencies due to red blood cell damage caused by oxidation.

Cognitive Decline

Excessive exposure of nerves to free radicals may result in damage over time. This damage may contribute to memory loss and other neurodegenerative diseases. Alzheimer’s disease is one such disease that may evolve as a result of free radical damage.

Experts suggest that consumption of a vitamin E supplement, such as tocofersolan may provide protection against the disease. Research studies involving over 300 Alzheimer’s patients found less deterioration over time. Each patient was administered 2000 IU per day. Less of these patients needed institutionalizing due to memory problems. However, these patients did experience more falls due to balance problems.

Another study involved patients between 65 and 102 year of age who were given vitamin E. Over a 3 year time period, these patients experienced less cognitive decline than similar patients who were not receiving vitamin E. Some groups did not show any improvements after being administered 2000 IU per day. Therefore, more studies should be conducted to determine the efficacy of vitamin E supplements in patients who may be healthy or suffering from Alzheimer’s disease.

Precautions when Taking Tocofersolan

Before beginning a tocofersolan regimen, consult with a physician. Inform the physician of all known allergies and other health problems. The physician will recommend a dosage to meet the patient’s particular needs. Patients who are suffering from the following conditions should exercise extra caution before starting a vitamin E regimen:

  • Blood Clotting/Bleeding Problems
  • Stomach Ulcers
  • Hemophilia
  • Low Platelets
  • Stroke
  • Liver Disease

Patients, who may undergo surgery, should consult with the surgeon prior to the procedure. The doctor may recommend that patients cease their vitamin E regimen until the surgery is complete. Also, discuss any potential risks of consuming vitamin E during pregnancy with your physician. This will avoid any unpredictable side effects that may be associated.

Drug Interactions

Before beginning a vitamin E regimen, inform the physician of any medications you are taking. The physician will make informed recommendations regarding dosage and other interactions that may occur. Some common drug interactions may include the following:

  • Amprenavir
  • Antiplatet Drugs, such as aspirin, clopidogrel, and ticlopidine
  • Blood Thinners, such as warfarin
  • Herbal Products, such as garlic or gingko
  • Cyclosporine
  • Fat-soluble supplements, such as vitamin A, vitamin D, vitamin E, vitamin K, and coenzyme Q
  • Iron supplements
  • Selenium
  • Vitamin C
  • Beta-Carotene

The list of all possible interactions is not exhaustive. Keep both the physician and pharmacist informed of each medication to avoid unpleasant side effects. Make note of other products containing vitamin E. This will aid in avoiding over consumption of vitamin E and causing adverse effects.

Vitamin E may also interact with Simvastin or Zocor and Niacin. The two used in conjunction with one another appear to lower high density lipoproteint (HDL) cholesterol levels. Oncologists cite risks of using any antioxidant supplement, including vitamin E, tocofersolan, with chemotherapy or radiotherapy. Oncologists suspect that the antioxidant may decrease the effectiveness of the treatment. The effectiveness may be lowered if the cellular oxidative damage is inhibited in cancer cells. Further studies are being conducted to evaluate the benefits of vitamin E supplements in cancer therapy.

Allergies and Side Effects

Individuals who consume vitamin E in the recommended doses typically do not experience side effects. Those who take vitamin E in high doses over a long period of time may begin to experience side effects. A large dose would consist of a dose over 400 units per day. Side effects may include the following:

  • Nausea
  • Diarrhea
  • Stomach Cramps
  • Tiredness
  • Blurred Vision
  • Headache
  • Rash
  • Itching
  • Swelling of face, tongue or throat
  • Dizziness
  • Wheezing
  • Trouble Breathing

Miscellaneous

Individuals who miss a dose of vitamin E should take the dose on the next scheduled time. Store vitamin E in an airtight container. Keep the product away from heat, light, and moisture. To dispose of the product do not flush the product down the drain. Inquire to find out the proper disposal of the product.

Herbs

Konjac

Konjac is a perennial plant of the genus Amorphophallus that grows in tropical and subtropical regions of eastern Asia, from Indonesia to India, Japan and China. It is known primarily for its starchy corm, a tuber-like structure that is actually part of the plants stem, but which grows underground and acts as a storage organ for the plant.

Konjac is also known as elephant yam, presumably for the resemblance of its corm to that of the true yam, but the plants are not closely related. Other colloquial names for Konjac are konjaku, devils tongue, snake palm and voodoo lily.

Konjac is primarily used as a source of glucomannan, a dietary fiber that makes up about 40% of the plants corm. Glucomannan is used as a food additive for its thickening and emulsifying properties, and as a nutritional supplement for the treatment of obesity, constipation, high cholesterol, diabetes and acne. It provides a rich source of soluble fiber, considered to be of general benefit to the digestive system, while containing almost no calories.
Konjac Benefits

Where it Come From

Konjac is cultivated in China, India, Japan and Korea. In nature, the plant grows best in tropical or subtropical conditions that provide moderate rainfall and a soil structure that combines a somewhat sandy top layer with a lower layer of mud that can retain water. In Japan and China, it is often cultivated in hilly terrain that is not conducive to traditional agriculture, and each plant requires very little room to get started.

Plants are typically transplanted and more widely spaced in their second and third years, at which time they reach maximum levels of glucomannan content. They are then dug out of the ground for cleaning and processing.

Processing

Traditional processing after the harvest is a very labor intensive operation. The corms are separated from the rest of the plant and washed and peeled by hand before being sliced and dried in the sun. Modern processing incorporates machinery and accelerates the drying process with air heated by burning coal. Regardless of the process used, the goal is to produce a product that is dry enough to be stored and to achieve greater concentrations of glucomannan.

The extent to which konjac is processed depends on whether its intended use is as a food, food additive or nutritional supplement.

Konjac flour is made by grinding the dry corms and separating the lighter components from the heavier flour. What is left contains approximately 70% glucomannan, and is suitable for use in noodles and other dishes. The flour can be further processed to achieve 80% glucomannan content, yielding konjac jelly or gum for use as a thickener or gelling agent, or purified as part of a final stage that produces the soluble fiber used as a nutritional supplement.

History and Origin

Konjac is regularly mentioned in historical Chinese treatises and histories, both as a medicine and, particularly in times of famine, as a food. The earliest known use of konjac as a medicinal herb dates back to the Han Dynasty in China, some two thousand years ago, where it was recommended as a treatment for asthma, infection, cough and skin disorders. Its use continued through subsequent dynasties and has been essentially uninterrupted through the present day.

Konjac, in both flour and jelly form, has a long culinary history in China and Japan. In Chinas Sichuan province, the jelly is used as a tofu substitute and called konjac tofu.In Japan, where it is called konyaku konjac flour is mixed with water and limewater and boiled. Once it solidifies, it can be cut into various shapes. Cut into thin wafers, it can take the place of tofu or thinly sliced raw fish. It is perhaps best known, however, when cut into strips and takes the place of noodles in several stew-like dishes, where it is appreciated for its unique texture. Konjac itself has little or no taste.

Western interest in konjac and glucomannan has grown over the past two decades as the health benefits of dietary fiber have become better understood. Research has focused on its potential for controlling cholesterol and blood glucose, as an aid to losing weight and as a general benefit to digestive health. Results of those studies have been promising. The broader therapeutic claims of traditional Chinese medicine have not been subjected to the same scrutiny and remain unproven.

Uses and Benefits of Konjac

Today, konjac is used for two distinct but related purposes: losing weight and supplementing dietary fiber. Both uses find support in the medical literature, but konjac has also been the subject of unproven claims that have resulted in government intervention.

Weight Loss

The efficacy of konjac for weight loss relies on its ability to absorb up to twenty times its own weight in water. The glucomannan expands after ingestion, and this tends to promote a feeling of fullness as it travels through the digestive tract. To achieve this result, konjac is generally taken with water before meals. An alternative, if less popular, approach is to sprinkle granules of glucomannan directly on food.

Recommended doses for weight loss purposes range from one to four grams of glucomannan taken with eight ounces of water one hour before each meal.

Fiber Supplementation

The American Dietary Association recommends that adults should consume at least 20 to 35 grams of fiber each day. The typical American diet provides between 12 and 18 grams. While oat bran, at 14% soluble fiber content, offers the most concentrated sources of soluble fiber among those catalogued by the ADA, glucomannan comprises at least 40% of konjac by dry weight, making konjac the richest source of soluble fiber in nature.

Clinical studies specific to glucomannan supplementation have shown positive results in the treatment of a number of conditions, including:

Constipation

Soluble fiber absorbs water, softens digestive contents and increases stool volume.

Hyperglycemia and Hypoglycemia

Glucomannan attracts water in the digestive system and becomes a gel, slowing digestive processes and trapping carbohydrates so that blood sugar levels are stabilized.

Diabetes

One benefit of the ability to regulate blood sugar levels is seen in Type 2 Diabetes, where glucomannan has shown potential to reduce blood glucose, insulin and serum lipid levels after meals, an effect that seems to be enhanced by glucomannans relatively high viscosity compared to other soluble fibers.

High Cholesterol

By attaching itself to bile acids in the digestive system and moving them out of the body, glucomannan supplements can help lower cholesterol and reduce the amount of fat present in the blood.

High Blood Pressure

As a corollary to glucomannans beneficial effect on cholesterol levels, one study has demonstrated a decrease in systolic blood pressure in healthy men after a four week course of glucomannan supplements.
Using Konjac
While all of the above benefits are supported by medical research on human test subjects, the clinical studies themselves have uniformly involved relatively small groups of people and short periods of time. It is unclear, then, if the beneficial effects of konjac supplements can be counted on to persist over the long term.

In addition, some studies, even those not looking specifically at glucomannan as a weight loss product, have limited their subjects to people who are obese, making it unclear if konjacs benefits extend to people who are not overweight.

However, soluble fiber in general has been studied extensively, with a great deal of attention to the fact that it produces short-chain fatty acids as it is digested. These acids, in turn, provide a number of health benefits, including:

  • Decreasing synthesis of cholesterol by the liver
  • Regulation of insulin release by the pancreas
  • Regulation of glucose absorption by affecting glucose transporters in the intestinal mucosa
  • Discouraging the formation of polyps by raising the acidity level of the colon
  • Enhancing the absorption of minerals, especially calcium, in the digestive system
  • Increasing the production of a variety of cells and antibodies involved in the immune system
  • Decreasing the ability of irritants to adhere to the mucosal layer of the colon

Konjac has itself been claimed to be something of an antidote to food poisoning. This claim originates from a single laboratory study in which 18 different food products were subjected to exposure to bacteria, including E. Coli and Salmonella, which were allowed to bind themselves to the products.

When the levels of bound bacteria were measured, the largest quantity were bound by sesame seed extract and konjac gum, leading to the tentative conclusion that konjac may help to prevent bacteria from entering host cells. This claim awaits further confirmation, as the effect has not been studied in a clinical setting to date.

Unproven Claims

A number of companies have been sanctioned for making false or misleading claims about the benefits of konjac and glucomannan. The sanctions have generally resulted from the companies exaggeration of the benefits conferred by konjac, from false claims of research support for those exaggerated benefits and from the use of expert endorsers whose expertise and qualifications are similarly exaggerated.

A typical example involves two products called FiberThin and Propolene, which were advertised via infomercials that claimed they would cause rapid and substantial weight loss without any need to exercise and regardless of what the consumer ate. The Federal Trade Commission required the companies involved to pay $1.5 million in settlement of the claims. They were also barred from making unsubstantiated claims for dietary supplements and from misrepresenting scientific studies in their marketing.

A different unproven claim may have its origin in the recommendations found in ancient Chinese herbal texts that list konjac as a treatment for acne and other skin conditions. Today, konjac can be found in several cosmetics and beauty treatments, which typically characterize it as a component that increases the effectiveness of other ingredients. There does not appear to be any research, pro or con, involving these claims.

Side Effects and Cautions

Konjac is not known to have undesirable side effects when used in food preparation or when taken as directed as a nutritional supplement, and its negligible calorie content make it particularly suitable as an aid to weight loss.

This is not to say that it is absolutely safe. Dangers associated with glucomannan stem from its ability to increase in volume by absorbing large quantities of water. These dangers have led to government intervention of two varieties:

Warnings

Products containing glucomannan have been required to include information warning consumers of dangers if the product is not consumed as instructed. For example, Health Canada issued a warning in 2010 that glucomannan in tablet, capsule or powder form should always be taken with at least eight ounces of water and that it should be entirely avoided immediately before bed. Products containing glucomannan are required to carry those instructions and to note the risk of choking and/or blockage of the throat, esophagus or intestine if the product is taken without sufficient liquid.

Bans

In 2001, several deaths and near-deaths of children and the elderly from suffocation while eating a certain type of konjac fruit jelly candy were reported in California. Unlike jellies that melt on contact with saliva, konjac jellies require chewing and, if unchewed, can be inadvertently sucked into the throat. As the jelly expands, breathing can be cut off. The Food and Drug Administration banned sale of the candies in the United States in 2001, a ban followed soon thereafter by the European Union, Canada and Australia. The candies are still available in parts of Asia, but are sold with warning labels and manufactured in larger sizes and in formulations that dissolve more easily.

Dosage, Administration and Cost

As a nutritional supplement, konjac is available in tablet, capsule and powder form. Dosage consists of the equivalent of 500 to 1500 milligrams taken before meals with at plenty of water. If using the powder, it should be stirred briskly in water and it is important to drink the solution before it has a chance to gel.

Konjac can be readily found online or at retail drugstores and nutrition stores like GNC. It is most commonly sold in capsules containing approximately 700 milligrams of glucomannan. Prices are extremely variable, ranging from under $3.00 to almost $20.00 for 100 capsules. Konjac powder can be a cost-effective alternative, but with similar pricing variability. At the extremes, a 500 gram bag of powder can be purchased for $18.00, while buying 500 grams in 100 gram bottles can cost at least five times as much.

Konjac is also found in multi-ingredient supplements, where it is frequently combined with other fiber sources or with ingredients claimed to be effective in losing weight.

Additional Availability

Konjac is also available as a food product, most often as noodles in a variety of shapes and sizes. Some brands have added flavoring, as konjac imparts little or no flavor on its own. Prepared noodles can be found online or at Asian grocery stores and are typically sold packed in water in plastic bags. They can be stored at room temperature and have a shelf life of approximately one year.

For the truly determined, konjac powder can be mixed with water and pickling lime in order to make konjac noodles from scratch. The mixture is boiled for three minutes and allowed to cool. Once cooled, it forms a stable, non-reversible gel which can then be cut into whatever shape is desired.

Antioxidants

Gallic Acid

Gallic acid is an organic acid found in a variety of foods and herbs that are well known as powerful antioxidants. Foods and herbs such as blueberries, walnuts, apples, flax seed and tea all contain Gallic acid. Gallic acid is also found in gall nuts, sumac, witch hazel, watercress, oak bark, and a variety of other plants and herbs. Gallic acid is also found as part of tannins, which are astringent, bitter plant polyphenols.

To obtain Gallic acid in a pure form, one must obtain it through an extraction process from gall nuts. First, finely-powdered nut galls are obtained. The powdered galls are mixed with distilled water to make a thin paste. The paste is then exposed to air, allowing it to stand in a warm place for about 4 weeks, ensuring that it has enough water at all times to maintain a pasty consistency.
Gallic Acid Definition
The paste is in a porcelain or glass container, avoiding the use of iron since iron or the presence of iron salts gives the product a color that is difficult to remove. After exposing the mixture to air for the required time, the paste is expressed and the residue is boiled with distilled water for a short time.

The boiled water and paste is filtered through charcoal while hot. When cooled, crystals of Gallic acid are formed. Sometimes further purification is necessary and the crystals are dissolved, treated with charcoal and re-crystallized.

Past Uses of Gallic Acid

Many of the foods containing Gallic acid have been used for years as natural remedies, and were relied upon by various cultures for their medicinal properties. Blueberries, for example, were used by Native Americans and the early American settlers.

Native Americans used blueberries to make an aromatic tea that was used as a relaxant during child birth—a popular usage for berries (rich in Gallic acid) that continued to be used by women of the early American settlers. Tea from blueberry leaves was also believed to be a good tonic for purifying the blood.

Another plant (also rich in Gallic acid) that has long been used for its medicinal properties is witch hazel. Native American tribes made balms out of the bark of witch hazel, and made tea from its leaves. The balm and tea were applied to cuts and wounds to prevent infection, and the tea alone was used to treat menstrual problems, colds and other illnesses.

The list could continue for each of the foods where Gallic acid is present, for ancient cultures quickly learned of the beneficial properties of the plants and herbs that surrounded them, and many herbs and healthy foods contain Gallic acid. The ancient cultures may not have understood the role of Gallic acid, or even that Gallic acid existed, in the foods and herbs they used for medicinal purposes. They did, however, believe that their medicines worked.

Efficacy of Ancient Use of Gallic Acid

Ancient cultures often believed in remedies and medicines that have later been proved to have been ineffective. For example, it was once believed that withdrawing large amounts of blood would cure or prevent illness. We know now, however, that removing large quantities of blood actually weakens an individual and facilitates illness.

However, the usage of foods and herbs rich in Gallic acid in ancient cultures was not entirely inaccurate. In actuality, these medicines and treatments using foods and herbs rich in Gallic acid often did work (though not with 100% accuracy).

Witch hazel, for example, does prevent wounds from being infected and does work as an astringent to constrict tissues and stop bleeding, therefore making the use of the plant effective in the ways in which the Native Americans were applying it.

However, witch hazel has now been determined unsafe for pregnancy, proving that while ancient medicine using items rich in Gallic acid may have been correct in some cases, it was not correct in all. Though ancient cultures were likely not aware of the properties in the foods and herbs that made their usage effective, we know now that the presence of Gallic acid played a significant role in the efficacy of such treatments and medicines.

Modern Use of Gallic Acid

Today, Gallic acid is believed to have health benefits that are of particular note to those at risk for certain forms of cancer or neural disorders. Studies have shown that Gallic acid is effective in inhibiting neuronal death. Studies have also shows that Gallic acid has anti-cancer properties against leukemia, certain prostate, colon and lung cancer cells.

Gallic acid has been shown to prevent cellular mutations and to be toxic to cancer cells, while having no negative effect on healthy cells. This, of course, means that Gallic acid may prove to be an effective treatment for certain forms of cancer, and that increasing the amount of Gallic acid consumed may help those suffering from cancer in their fight against the disease.

In addition to the health benefits for people at risk for certain forms of cancer or neural disorders, Gallic acid also has anti-viral and anti-fungal properties. It is a powerful antioxidant that helps to prevent oxidative damage. Gallic acid also has therapeutic applications for inflammatory allergic diseases, such as asthma, allergic rhinitis, sinusitis due to its ability to inhibit histamine release and the expression of pro-inflammatory cytokine.

Finally, Gallic acid can be used as a remote astringent, as it works to constrict tissues and stop bleeding. Administered internally, Gallic acid has shown to be an effective astringent that is beneficial in the treatment of uterine, pulmonary, and nephritic hemorrhages, as well as all hemorrhages of a passive character.

As a remote astringent, Gallic acid has also proved to be effective in the treatment of regular, unusually heavy and prolonged menstrual periods (also known as Menorrhagia). In fact, Gallic acid has shown to cease the occurrence of Menorrhagia when the individual takes 5 grains of Gallic acid in pill-form 3 – 4 times per day during the flow.

Modern Forms of Gallic Acid

Because Gallic acid has been shown to be so beneficial to overall health, it is important to know how we can increase our intake of the antioxidant. There are not supplements specifically of Gallic acid. However, there are plenty of readily available vitamin and nutritional supplements that contain Gallic acid and will help to give the benefits associated with Gallic acid. Most of these supplements are specifically designed to be rich in antioxidants.

Some examples of pill form supplements that include Gallic acid are Grape seed extract, Rooibos Tea Extract, Amla and Livotide, among others. It is also possible to increase intake of Gallic acid through natural juices, such as pomegranate, blueberry and grape juice, or through consuming foods naturally rich in Gallic acid.

Vitamin supplements containing Gallic acid in pill form are available at local nutritional and health stores, as well as through various online retailers. Prices vary depending on the brand purchased and the retailer where the product is purchased. However, different supplements containing Gallic acid can be found for prices ranging from $6 to almost $100.

It is important to note that many of these supplements include a variety of other vitamins and herbs that are thought to beneficial to health. The price of the product purchased will also be affected by the other ingredients included in the supplement, as well as the amount of capsules in each bottle. Obviously, bottles that hold hundreds of pills are going to be more expensive than small bottles holding less than one hundred.

When taking supplements, or any medication, it is important to follow the directions given by a medical professional or on the label of the medication or supplement. It is believed that Gallic acid is safe in any dosage. However, Gallic acid is most often found in supplements containing other ingredients. Therefore, the instructions on the bottle must be followed carefully.

Side Effects of Gallic Acid

In animal studies, Gallic acid has triggered contractile responses and inhibited the decrease of vascular pressure in the thoracic aorta. Gallic acid has also been shown to interfere with medications taken for high blood pressure. Therefore, if you are taking medications for high blood pressure or are at risk for heart problems, a medical doctor should be consulted before increasing your consumption of Gallic acid through the use of nutritional supplements.
Side Effects of Gallic Acid
Gallic acid has been shown to have immense health benefits, and may prove to be an effective treatment for certain cancers and neural disorders.

Its use as an antioxidant helps to ensure overall and continued health, and can be taken as a supplement to increase the levels of this beneficial antioxidant in your life. However, as with all nutritional supplements, it is not a substitute for an overall healthy lifestyle through a healthy diet and regular exercise.

Also, as with all exercise and nutritional plans, you should talk to your doctor or naturopath regarding supplementing your diet. This not only ensures the proper ingestion of the supplement, but will also ensure that there is no conflict between medicines being taken and the supplement.

Resources

CDC.Gov
MedicineNet.Com

Conditions

Gout

Alternative names

  • Hyperuricemia
  • Asymptomatic Gout
  • Acute Gout or Gouty Arthritis
  • Interval and Intercritical Gout
  • Chronic Tophaccous Gout

Symptoms

Gout.

There are two different types of gout, primary gout and secondary gout. Primary gout is inherited, which consists of the over production of the uric acid in the blood, a decrease of uric acid in the urine, or both.

Secondary gout occurs when the medication causes the increase of uric acid in the blood. Diuretics can cause this. Kidney failure or the increased destruction of cells, such as cancer patients going through chemotherapy, are also attributed to secondary gout.

You will have redness of the joint accompanied by stiffness, inflammation, and extreme pain. Many will suffer from podagra, a condition where gout forms in the big toe, but you can also contract gout in other joints such as ankles, wrist, fingers, or elbows. 75 percent of first attacks start in the big toe.Gout Remedies

Any type of pressure on the affected area hurts. Something as light as a bed sheet or your sock can cause extreme pain. Gout attacks can get better within a few days, even without treatment.

Four Stages With Different Symptoms:

  • Asymptomatic (without symptoms) Hyperuricemia are elevated levels of uric acid in the blood with no symptoms.
  • Acute Gout or Gouty Arthritis is when deposits of uric acid crystals form in the joint spaces. Sudden onsets of pain will follow, along with swelling, heat, and tenderness.
  • Interval or Intercritical Gout is the period in between attacks where there are no symptoms.
  • Chronic Tophaccous Gout is the most severe and disabling of all stages of gout. It develops over years, causing permanent damage to any of the joints that are affected, and in some cases, the kidneys.

Causes

If there an increased production in uric acid and your kidneys are doing what they need to do to eliminate the acid, it will build up in the blood, a condition called Hyperuricemia. The uric acid forms tiny crystals the size of the point on a needle in the joints or soft tissue. The crystals can also form into kidney stones.

Risk factors

  • Genetics makes up about 20% of all people who suffer from gout.
  • Gender and Age: Gout is more common in adult men between the ages of 40 and 50, with a peak age of 75,
    are more likely to contract gout than woman, children, and young adults.
  • Weight: Being overweight increases the risk contracting gout. The more you weigh, the more frequent the attacks. Having the extra weight makes it harder for the body to do its job. Losing the weight gradually willbe a benefit to those who have high levels of uric acid, even though being on a diet can trigger an attack.
  • Alcohol: People that drink too much alcohol can contract gout as well. The more alcohol you drink, the more the blood is not able to remove the uric acid, the rest crystallizes. Gout attacks happen because the major consumption of alcohol impairs the kidney function.
  • Lead: Some studies have concluded that there’s a strong connection between gout and lead poisoning.
  • Other risk factors that can cause gout are certain foods such as anchovies, asparagus, beef kidneys, dried bean or peas, game meats, gravy, liver. There are so many others, but these are definitely the foods that gout sufferers should watch out for.
  • The kidneys that possess an inability to eliminate waste products.
  • People that suffer from high blood pressure.
  • People who have had organ transplants.
  • Hypothyroidism, or under active thyroid.

Prevention tips

  • Medications: Non steroid anti-inflammatory drugs, or NSAIDs, help with the pain and inflammation, oral
  • Colchicine in small does to prevent future attacks. Zyloprim and Benemid are medications that are used for the treatment of Hyperuricemia.
  • Zyloprim can help in the management of uric acid, but it won’t stop an acute attack of gout that is already present. It can, however, reduce your symptoms when taken over the course of several months.
  • People that use medication for high blood pressure and high blood triglycerides find that these meds can be used for the treatment of gout. Cozaar, a high blood pressure medication, and Tricor, a triglyceride lowering medication, are the two that have been found to help aid in the treatment of this condition.
  • Lifestyle Changes: Controlling your weight keeps the body from having to work harder break down the bodily waste.
  • Drinking large amounts of water removes uric acid from the body.
  • Avoid diets that have a low-carbohydrate intake. When you’re not taking in a substantial amount of carbohydrates, the body can’t burn fat completely.
  • Eating foods that are purine free is key to reducing the frequency of gout attacks. Purine free means that foods that don’t have a nucleus such as an egg. The yolk is the nucleus. They can’t be avoided completely because purines are released when the body recycles dead cells. These foods are egg whites milk and milk products like cottage cheese mozzarell and whey protein, and pulp-free fruit juices.
  • When you have an attack, it is important to avoid excessive exercise, don’t starve yourself, and don’t reduce you calorie intake. The body will continue to break down body tissue and not getting the proper intake of calories per day, the body will compensate by accelerating the breaking down process.

Test and diagnosis considerations

To confirm a diagnosis, a doctor will inject a needle into the inflamed joint and pull a sample of the liquid that lubricates the joint called synovial fluid to analyze. If there are uric acid crystal found in the joint spaces, then you have gout. X-rays don’t work in the early stages of gout, only when the disease is in its later stage, will you see parts of the joint that have been worn away or eroded.
Treat Gout Naturally
Patients will often seek medical attention thinking that finding the gout in its early stages will prevent it from getting worse later. Sometimes symptoms of gout can be confused with another form of arthritis. One form is called pseudogout. It resembles all the symptoms of gout, but instead of having uric acid crystals that form in the joint spaces, it calcium phosphate. In this case, pseudogout.

Treatment options

1. Home treatments

  • Warming the joints with a foot bath and heating pad can help relieve joint pain.
  • Increasing the amount of water that you drink will increase your urination, which decreases the amount of
    uric acid in your blood. According to the Institute of Medicine, men should drink approximately 13 cups of
    water per day, women should drink approximately nine cups, whether it’s in food or drink.
  • NSAIDs, with the help of other prescribed drugs, are used to treat gout. Aspirin should not be taken
    because it can aggravate the condition.
  • Corticosteroids can relieve pain and inflammation of gout in the joint by injecting it right into the joint if
    the pain medication that you have at home doesn’t work.
  • Doctors have been advising patients who suffer from gout to take Vitamin E, B-complex, and folic acid to
    replenish the body’s supply.

This should be done under supervision of a physician, but a solution of half of a teaspoon of baking soda dissolved into a glass of water on an empty stomach. If the stomach is full, the combination of the stomach acid and the water/baking soda solution will turn the water into carbon dioxide gas.

The gas will increase stomach pressure, causing injury. Do not exceed more than seven 1/2 teaspoons or three 1/2 teaspoons if you’re over 60, in a 24 hour period. Don’t exceed the maximum dosage for more than two weeks.

Herbal Remedies

In folk medicine, eating or drinking cherries in various forms has shown to reduce the inflammation caused by gout. They have been promoted to the preventing or treating of the condition.

Other herbal remedies that people tend to use instead of conventional medicine are things like celery seed
oil, cherries or cherry extract, turmeric, artichoke extract, garlic, and various Chinese herbs.

Some people have found that swallowing a teaspoon of celery seed oil gives relief for people suffering from gout. It has been used as a herbal remedy to help with conditions where inflammation is a symptom and rheumatism. Turmeric is known in many countries for its health benefits. In Pakistan, it is used as an anti-inflammatory.

The herbal remedy Flamasil, which is turmeric based, it helps with the degeneration of cells, which is 70 percent of all uric acid production, enhances liver and kidney function, and blocks the enzyme that produces uric acid. With any home remedy or experimental drug, there will be opinions and criticisms about how well or if it works.

Side Effects

The side effects of oral colchicine is usually nausea, vomiting, abdominal cramps, or diarrhea. These side effects make it difficult for the patient to continue using the drug. Corticosteroids cannot be used for every attack you have. If used over time, it can cause deterioration of the joints. It can also decrease the ability for the body to fight off infection and may make these infections harder to treat. You might also notice an increase or decrease in appetite, nervousness, restlessness, problems sleeping, and indigestion.

If you’re using a corticosteroid, via inhalant, you’re more likely to suffer from dry throat as well as headaches, nausea, bruising and/or thinning of the skin, unpleasant sense of taste. Nasal sprays can also irritate the throat, and ointments or gels can cause skin irritation.

Probenicid, or Benemid, is not a good medication to treat acute gout attacks. They can aggravate the inflammation if used in the beginning stages of the attack. It can also cause kidney issues such as renal colic and increased levels of uric acid that can turn into uric acid stones, or kidney stones. Zyloprim side effects are included, but not limited to, an acute attack of gout, nausea, diarrhea, and certain skin reactions such as a rash.

All gout medications have side effects that range from nausea to stomach cramps. Although, there are new medications being developed in clinical trials that will substantially increase the elimination of uric acid and the lowering of uric acid in the blood stream. Researchers are also working on medications that will stop chemical messages that are causing the gout inflammation.

Chinese Research

In China, researchers have invented a medicine that compliments, the Weicao Capsule, that helps relieve gout, therapeutically. This is still in its trial phase, but it has been shown in a study that the capsule has increased urination, which lowers high levels of uric acid and improves kidney function.

Gout can become extremely serious if not treated in it’s earliest stages. There are some people that will dismiss the condition, but gout is very serious and has the capability of interfering with the simplest of everyday things.

Resources

National Institute of Health
Cdc.Gov
MedicineNet.Com

Vitamins

Vitamin E

Vitamin E is a broad-term that commonly refers to a group of eight fat-soluble compounds with antioxidant activity. Vitamin E works in the body by preventing oxidation and damage to cells caused by free radicals. When free radicals react with oxygen the body naturally produces reactive oxygen species that damage cells.

Not only is vitamin E a powerful antioxidant, it also protects essential fatty acids and Vitamins A and K. Vitamin E was discovered in the 1920s and synthesized for the first time several years later. Although vitamin E is an antioxidant it seems deeply connected with regeneration and the health of cells. Vitamin E is broken into two groups, tocopherols, which are more common, and tocotrienols, which were discovered later and are different from tocopherols in their isometric construction.
Vitamin E Pills
Vitamin E is naturally present in vegetables, fruits, seeds, grains, and nuts. Due to the fat-soluble nature of vitamin E, foods rich in these vitamins are often have a high fat content, like avocados or wheat germ. Vitamin E includes four tocopherols and four tocotrienols both with four sub-classifications Alpha, Beta, Gamma, and Delta.

The body uses vitamin E by absorbing it in the small intestines. The liver then processes the vitamin E and selectively secretes only alpha tocopherol, using a special protein. Since alpha tocopherol is the only form of vitamin E retained in the body and present in blood it has been studied more than any other.

List of E vitamins

Tocopherols

  • Tocopherol (Alpha tocopherol)
  • Tocopherol (Beta tocopherol)
  • Tocopherol (Gamma tocopherol)
  • Tocopherol (Delta tocopherol)

Tocotrienols

  • Tocotrienol (Alpha tocotrienol)
  • Tocotrienol (Beta tocotrienol)
  • Tocotrienol (Gamma tocotrienol)
  • Tocotrienol (Delta tocotrienol)

Functions and Health Benefits

In vitro cell studies have shown vitamin E prevents blood from adhering to artery walls, dilates blood vessels, and prevents platelets from sticking and forming clots.

  • Vitamin E helps the body to use vitamin K more effectively.
  • Red blood cells are formed with the help of vitamin E.
  • Vitamin E in involved in the function of a healthy immune system.
  • Although less than 1% of vitamin E studies are on tocotrienols, there is evidence they may specialize in protecting nerve cells and neurons.

Deficiency

Symptoms of vitamin E deficiency can include anemia, muscle weakness, loss of muscle mass, loss of muscle tone, problems transmitting nerve impulses, issues with stability and balance, degeneration of the retina, problems seeing, and difficulty controlling eye movement.

Vitamin E deficiency is very rare in healthy adults with an average caloric intake. People with serious medical conditions that effect fat absorption are most likely to suffer from a vitamin E deficiency. Medical conditions that affect fat-absorption in the intestines include Crohns disease, cystic fibrosis, problems with the pancreas, chronic diarrhea, and greasy stools.

There are also severe very rare medical conditions that prevent-fat absorption, including a genetic condition called abetalipoproteinemia, which requires massive doses of Vitamin E for ever pound of body weight and AVED Ataxia and Vitamin E Deficiency is genetic condition where the protein in the liver that secretes vitamin E is totally absent. People with these rare conditions need to take vitamin E supplements to prevent the symptoms of deficiency from occurring.

Premature babies with a very low birth weights are at an increased risk for vitamin E deficiencies, adding a vitamin E supplement could help eye health but may increase the risk for infections. Talk with your healthcare provider about the risks and benefits of a vitamin supplements for newborns. The Recommended Dietary Allowance for children under six months of age is 4 milligrams or 6 international units.

Dietary Sources

Vitamin E is naturally found in eggs, fish, dark leafy greens, bright orange vegetables, seeds, nuts, and grains. Fruits and vegetables rich in fat also contain vitamin E. In the US fortified cereals are supplemented with vitamin E, mainly in the form gamma tocopherol. In vitro and animal studies have recently indicated gamma tocopherol may be a potent anti-inflammatory and antioxidant. Population studies are currently being conducted on the effective of gamma tocopherol on cardiovascular disease and cancer risk.

  • Proteins, fats, and oils
  • Eggs
  • Fish
  • Crustaceans
  • Sardines
  • Herring
  • Margarine
  • Vegetable oil
  • Canola oil
  • Peanut oil
  • Corn oil

Fruits and Vegetables

  • Green and orange fruits and vegetables are particularly high in vitamin E.
  • Mango
  • Papaya
  • Oranges/orange juice
  • Tomato
  • Sweet potato
  • Sweet Red Peppers
  • Carrots
  • Apricots
  • Peaches
  • Raspberries
  • Blackberries
  • Asparagus
  • Spinach
  • Avocado
  • Turnip Greens
  • Dandelion Greens
  • Collards

Seeds, Nuts, and oils

  • Roasted sunflower seeds are extremely high in vitamin E.
  • Almonds
  • Brazil Nuts
  • Peanuts
  • Peanut butter
  • Wheat bran contains 100% of the daily vitamin E requirement in one tablespoon.
    • 0 to 6 months: 4 mg/day
    • 7 to 12 months: 5 mg/day
    • Children
    • 1 to 3 years: 6 mg/day
    • 4 to 8 years: 7 mg/day
    • 9 to 13 years: 11 mg/day
    • Adolescents and Adults
    • 14 and older: 15 mg/day
    • Antidepressants
    • Antipsychotics
    • Blood pressure medications that use beta-blockers
    • Cancer and chemotherapy drugs
    • Statin drugs for high cholesterol, including Zocor, Lipitor, and Crestor
    • Bile acid sequestrants used to treat high cholesterol.
    • Vitamin E may counteract the side effect of the HIV/AIDS medication AZT.
    • The weight loss medication Alli prevents vitamin E from being absorbed.

Health benefits and Effectiveness

Due to correlations between certain medical conditions and low Vitamin E blood serum levels alpha tocopherol has been studied for its effectiveness of everything from cancer to Alzheimers and sun sensitivity. Unfortunately, vitamin E has not proven to be consistently effective in preventing these health conditions in long term population studies, lasting four to eight years.

Heart Disease

Population studies have shown patients with lower risk of heart disease were found to have higher levels of vitamin E. Leading scientists hypothesize that vitamin E was responsible for the correlation; studies have not been so conclusive. One of the largest studies on vitamin E and heart health the Heart Outcomes Prevention Evaluation (HOPE) trial showed that daily consumption of 400 IU of vitamin E did not lower the risk of heart disease-related deaths in men and women who were at a high risk.
Vitamin E Deficiency
Likewise, the Physicians’ Health Study II tracked more than 14,000 male doctors at a low risk for heart disease and proved that consuming 400 IU of vitamin E every other day for eight years did not reduce the risk of cardiovascular attacks.

One study with positive results showed that postmenopausal women who consumed foods rich in vitamin E lowered their risk for stroke-related deaths. However, the same study showed that vitamin E supplements were not an effective preventative strategy.

Congenital Heart Defects

According to studies in the Netherlands and the National Health Service in the UK, mothers with high vitamin E diets and those who consumed vitamin E supplements, while pregnant and before conception, have a nine-fold increased for delivering a child with congenital heart defects (CHD.)

The data in this study was limited because mothers were questioned about their diet when children were already 16 months old, so its not a good indication of the diet before or during pregnancy.

Officials in the UK warn against taking vitamin E supplements during pregnancy, saying consumption equal to 75% of the daily allowance could be too much vitamin E, leading to an increase rick for congenital heart defects in newborns.

Cancer

Although there have been studies showing a deceased risk for prostate cancer in patients with high vitamin E levels, this has not been backed up in large population studies. Despite a study on vitamin E showing a 30% reduction in prostate cancer, a clinical trial SELECT (Selenium Vitamin E Cancer Prevention Trial) carried out on 35,000 men for four years was subsequently cancelled after an independent panel showed no reduction in prostate cancer risk with vitamin E alone or a combination of selenium and vitamin E.

Another large population study on 29,000 male smokers showed lower prostate cancer risk and fewer deaths in patients who took 50 mg of vitamin E daily. One large eight-year study of men who took 400 mg of vitamin E every other day showed no reduction in overall cancer risk. Vitamin E in the form alpha tocopherol has not been proven to reduce breast cancer risk, or prevent lung or pancreatic cancer. Additionally, taking vitamin E supplements after diagnosis with cancer doesnt improve treatment, in fact, antioxidants may interfere with chemotherapy drugs. Talk to your medical provider before taking any vitamin E supplements if you are undergoing chemotherapy.

Vitamin E has also been studied on colorectal cancer, but hasnt been proven to reduce risk in women or diabetics. However, there is evidence that vitamin E in combination with vitamin A and vitamin C may protect people with benign tumors, considered a precursor to colon cancer.

Alzheimers Disease

Scientists have linked oxidation with the incidence of Alzheimers, unfortunately vitamin E has not proven to be consistently effective in slowing the onset of Alzheimers symptoms.

Once study, comparing vitamin E to placebo, showed these patients developed Alzheimers at the same rate, while another study on 340 patients, comparing vitamin E to placebo and a pharmaceutical Alzheimers medication selegiline showed that patients given 2,000 IU of vitamin E slowed the onset of the disease by 200 days, compared to placebo, but selegiline was more effective.

Eye Health

Vitamin E has been proven to play a critical role in eye health. A combination 400 IU of vitamin E, 80 mg of zinc, 15 mg beta-carotene, and 500 mg vitamin C benefits patients with advanced macular degeneration–the leading cause of blindness in people over 55. People with advanced macular degeneration had the greatest benefit from this treatment. Further research is needed to see if this treatment works to prevent AMD and if it is effective on less advanced cases.

A combination of vitamin E and vitamin C is also proven to help uveitis, an inflammatory condition affecting uvea a layer of the eye between the white part and the retina. Patients with uveitis who took vitamin E supplements had consistently clearer vision that those on placebo.

Recommended Daily Intake

The following is a recommended daily intake of vitamin E based on age, according to The Food and Nutrition Board at the Institute of Medicine. The recommended value depends on age, sex, and other medical factors. Always talk to your doctor before taking a vitamin E supplement.

Infants

Considerations

In 2004 the American Heart Association warned that high doses of vitamin E may be harmful, taking more than 400 IU of vitamin E per day may increase the risk of death. Small doses of vitamin E, like those found in multivitamins, have not been proven to be harmful.

Due to the complex nature of the immune system and antioxidant defense system supplements of vitamin E may not have the same effect as vitamin E found naturally in foods. Vitamin E in foods naturally contains many forms of tocopherols and tocotrienols. For best results eat a well balanced diet including all of the food groups.

Vitamin E supplements are available in soft gels, tablets, capsules, and topical oils. Vitamin E is naturally fat-soluble, meaning it is most commonly an oil, however, special water-soluble forms of vitamin E are available, these especially important to people who cant absorb fat.

Vitamin E is available in natural and synthetic forms. Natural vitamin E is sold as d-alpha-tocopherol and the synthetic form is always labeled dl-alpha-tocopherol.

Applying Vitamin E oil is one of the most popular home remedies for lessening the appearance of stretch marks, scars, and burns. Despite its popularity vitamin E is not proven effective at improving the appearance, size, or thickness if scars. Not only was vitamin E not effective but about one third of people in the study developed contact dermatitis from the topical application. Always test vitamin E oil on the inside on your arm before using.

Drug Interactions

Always check with your doctor before taking a vitamin E supplement, vitamin E reacts with many popular prescriptions. Do not take vitamin E if you are on any blood thinning medications, like aspirin, Warfarin and Coumadin, as it can increase the risk for bleeding.

Sources:

  • Healing Daily, Vitamin E Healing Daily.
  • Natural Standard Patient Monograph, Vitamin E MayoClinic.com.
  • National Institutes of Health, Vitamin E Office of Dietary Supplements NIH.
  • University of Maryland Medical Center, Vitamin E UMM.edu.
  • U.S. Library of Medicine and National Institutes of Health, Vitamin E MedlinePlus.
  • Dr. George Obikoya, Free Radicals and Vitamin E The Vitamins and Nutrition Center.
  • Dietrich M, Traber MG, Jacques PF, Cross CE, Hu Y, Block G., Gamma Tocopherol PubMed.gov.
  • USDA, USDA National Nutrient Database USDA.gov.
  • National Health Service, Babies at risk from Vitamin E NHS Choices.
  • Anahad O’Connor, The Claim: Vitamin E helps Remove Scars New York Times.
Conditions

Chicken Pox

Chicken pox, also referred to as Varicell disease, is classified as an infectious disease that particularly strikes children. However, chicken pox can affect persons of various ages and often does. Statistics indicate that over four million individuals in the United States alone are diagnosed with chicken pox annually and the incidence for chicken pox in many other countries remains much higher.

Symptoms

The hallmark symptoms of chicken pox include an itchy rash, fever, and headache. The rash tends to look like blisters and can most usually be found on the face, trunk, and sometimes the scalp. However, the rash can also spread to other areas of the body, including the eyes and mouth. Sore throat, chills, and profuse sweating may also accompany chicken pox. While many of these symptoms subside within ten days, serious complications resulting in hospitalization and even death can occur.

Complications

One of the most common complications of chicken pox is skin infection. The rash is extremely uncomfortable, causing itching and pain. Young children are especially prone to scratching, which can cause breaks in the skin. This allows a portal for microbes and other infectious disease. Once the chicken pox virus enters the body, it remains there and can also give rise to shingles later in life. One complication of chicken pox called Reye’s syndrome can easily be avoided by not administering aspirin to those with chicken pox.
Natural Chicken Pox Remedies
Dehydration can also become a concern with chicken pox, especially if the child has blisters in his or her mouth. Ensuring adequate fluid intake can prevent dehydration.

Adults suffering from chicken pox are at an elevated risk for both pneumonia and encephalitis. In rare cases, permanent neurological impairments have been known to occur. Other than Rye Syndrome, liver damage is possible. However, the inflammation is usually short term and will gradually go away.

Transmission

Chicken pox or Varicella disease is transmitted from person to person. Vaccination, avoiding contact with respiratory secretions, and limiting exposure to those lacking sufficient immunity can reduce the transmission of chicken pox. Immunity to the disease is permanent once exposed via vaccination or infection.

Prognosis

As previously mentioned, chicken pox can cause a variety of complications. Scarring is likely with chicken pox and will depend on the severity of the virus. Refraining from scratching and allowing the scabs to fall off can help reduce scarring.

Children usually make a full recovery from the disease and the majority of complications are most prevalent in adults. Chicken pox remains dormant in the body and symptoms can resurface at anytime in life.

This most often occurs later in life and/or when the immune system is lacking. The most common recurring complication of chicken pox is shingles. Shingles is characterized by severe pain and a rash that eventually develops into small blisters filled with fluid. Unlike chicken pox, the symptoms can last a month or more. During an outbreak of shingles, the individual can transmit the virus to others.

Causes and Prevention

Chicken pox is caused by the Varicella Zoster virus of the Herpes family. While there is no cure for this disease, it can often be prevented with vaccination. The Centers for Disease Control and Prevention recommends that children between the ages of twelve months and twelve years should have the vaccination in two doses, three months apart.

Children over the age of twelve should have two vaccinations within a couple weeks apart. Adults of high risk, such as the elderly and the immune compromised are also candidates for the Varicella vaccination.

However, those that have previously contracted chicken pox or have had shingles do not need vaccinated. Chicken pox infections can still occur despite vaccination. However, those who contract the disease after vaccination will typically have a shorter, milder duration of chicken pox.

Risks Associated with Vaccination

As with any other vaccination, there are some risks to the Varicella vaccination and it is not recommended for all persons. Pregnant women, patients undergoing chemotherapy and/or radiation therapy, those who may be allergic to the vaccine, seriously ill individuals, and anyone who has received a blood transfusion or blood products within the few previous months are not good candidates for vaccination. Persons suffering from mild illnesses can still have the vaccination though. Complications can easily be avoided by discussing the previous medical history with the physician.

Side Effects

Side effects of the Varicella vaccination are typically quite mild and may not occur in all individuals. The most common side effect noted is redness, swelling, and inflammation at the injection site. This is only temporary and typically goes away within a few days. Other side effects include fever, rash and/or bumps following the vaccination and occur in less than five percent of vaccination recipients. In some rare cases, chicken pox has been transmitted from the vaccinated individual to others.

Infection with the virus has occurred in only a small number of those that have been vaccinated. Serious side effects that are even less common include allergic reaction, encephalitis, seizures, and pneumonia. However, there is no evidence to indicate whether or not these reported incidents were actually caused by the chicken pox vaccination. The benefits of the vaccine outweigh the possible risks.

Risk Factors for Varicella Disease

Those most at risk for contracting chicken pox include those without sufficient immunity. This includes persons who have not been immunized and who have not had the disease. Infants, pregnant women, and those with weakened immune systems and/or certain medical conditions are also at high risk for the Varicella virus. Coming into contact with persons suffering from chicken pox significantly increases the chance for these individuals to contract the disease.

Certain geographical populations are also more prone to chicken pox outbreaks due to lack of herd immunity. For this reason, unvaccinated travelers are also considered high risk for contracting chicken pox. Another important risk factor is receiving an organ transplant. Transplant recipients are at high risk for developing not only chicken pox if not previously exposed, but developing shingles.

Diagnosis

Chicken pox can be diagnosed via a blood test. However, this is not usually necessary. Signs and symptoms alone are often sufficient enough to diagnose this disease. It is important that the child or afflicted individual be diagnosed by a licensed health care worker to rule out other conditions or illnesses.

Shingles may also be quite easy to diagnose clinically but a test known as the immunofluorescence assay test is a quick and convenient diagnostic tool most commonly used to detect Varicella when shingles is suspected.

Treatment

The treatment for Varicella disease is mainly symptomatic. Reducing pain, fever, and promoting comfort are all considerations. Over the counter pain reliever/fever reducers with the exception of aspirin and aspirin products are typically administered as needed. Acetaminophen, the main ingredient in Tylenol and other pain relievers is most commonly given. A physician may also prescribe topical ointments to relieve itching and/or antibiotic creams to prevent infection. Keeping the skin clean and intact is an important concern, especially in children.
Chicken Pox Treatment
Although there are anti viral drugs available, these are usually reserved for certain individuals. Antiviral drugs are mainly prescribed for adults and those at high risk for developing severe complications associated with chicken pox, those with weakened immune defenses and patients suffering from shingles.

Acyclovir, valacyclovir, and famcyclovir are generally the antiviral drug of choice for the Varicella virus.

Alternative Treatments

Some treatments for chicken pox are non pharmaceutical; these also are used to promote comfort and manage symptoms.

These treatments can consist of herbal supplements, plant extract, and vitamins. Since these products are not regulated by the Food and Drug Administration, it is recommended that a physician be consulted before attempting these alternative treatments for chicken pox.

Vitamins

Vitamins believed to be beneficial to those suffering from chicken pox include vitamin B-12, vitamin A with beta carotene, and vitamins D, E, and K. Advocates of this natural remedy for chicken pox note the properties of vitamin A and beta carotene to the skin and in fending off viral infections.

B-12 vitamins provide relief by helping the individual to feel better. Although many B-12 vitamins are available over the counter, injections of this vitamin can be provided by a physician. The remaining vitamins D, E, and K assist in the absorption of vitamin B-12 and A, as well as many other nutritional supplements.

Precautions should be taken, especially with children before providing vitamin supplements for treatment. Overdose of vitamins can have adverse health effects, leading to temporary or permanent disability and/or death.

Herbal Remedies

Most herbal remedies for chicken pox are topical mixtures that are safe for most children and adults. One of the most common herbal remedies is to create a mixture of rosemary, comfrey, and chickweed to soothe the skin. The convection is slightly warmed and applied to the skin using a clean cloth. To avoid rupturing of the blisters during the application process, the mixture should be blotted onto the skin gently. The herbs are applied as needed to soothe the itching, pain, and burning caused by blisters.

Lotions and Gels

There are a variety of lotions and gels over the counter and by prescription that may be used to treat chicken pox. Aloe Vera, Calamine lotions, Oatmeal pastes, and similar concoctions are used topically to promote comfort. Some may even be used in bath water or directly from plants, especially extracts such as aloe. Products similar to the Calamine lotions typically have antimicrobial properties to help prevent infection and reduce itching and inflammation of the skin.

Treatment Costs

The cost of treatment for chicken pox will vary depending on the methods implemented. Lotions and gels can typically be purchased from major retailers for under $10, while others can be safely and effectively made at home. Some herbal products may have to be purchased at specialty stores and costs will vary.

Risks Associated with Alternative Treatments

Alternative treatments for chicken pox can provide relief of symptoms but is not recommended for everyone. Overdose, allergic reaction, and/or infection can result. Those with specific plant allergies, small children and infants, those with a compromised immune system should not undergo these treatments without first consulting their primary caregiver/physician.

Other Considerations

Chicken pox is caused by a virus, as with any other viral illness, it must run its course. There is no cure for chicken pox. Treatment should revolve around promoting comfort, and preventing complications such as dehydration and infection. Drinking fluids, getting plenty of rest, and avoiding skin abrasion are crucial to those with chicken pox.

If symptoms do not improve within ten days, a physician should be consulted. Immediate medical attention may be required for fever over 104 F, when dehydration is suspected, changes in mental status, or if the symptoms become progressively worse. To help prevent the spread of the disease, exposure to infected persons should be limited.

Conditions

Hyperacidity and Heartburn

Hyperacidity occurs when the stomach releases a higher than normal amount of hydrochloric acid during the process of digestion. Hyperacidity also refers to the stomach simply containing an excess of acid.

The term heartburn refers to a sensation that can be described as feeling like burning and is felt in the chest area behind the breastbone. Though the pain will usually be felt in the chest, it may also radiate out towards the neck and throat area.

Stomach Acid

Heartburn may be experienced when there is a regurgitation of stomach acid (gastric acid). It also commonly occurs as a symptom of gastroesophageal reflux disease. The term acid reflux is often used interchangeably with heartburn. However, acid reflux is the action of the stomach acid leaking into the esophagus while heartburn is the associated sensation.
Heartburn Remedies
While most individuals experience infrequent and minor cases of heartburn, there is a severe condition known as GERD (gastroesophageal reflux disease) that affects some with symptoms far more often. This condition involves intense and frequent acid reflux and can lead to many potential health complications.

Alternative names

Hyperacidity is alternatively referred to as acid dyspepsia or Amalpitta.

Heartburn is alternatively referred to as acid indigestion or pyrosis.

Symptoms

The most common symptoms associated with hyperacidity and reflux are:

  • The sensation of heartburn occurring after eating. Pain may last for a few minutes or up to several hours.
  • A pain in the chest area that can get worse when lying down or bending over.
  • A painful burning sensation occurring in the throat. Can be accompanied by an acidic taste in the mouth or the sensation of a sour or bitter liquid in the back of the throat.
  • A sore throat or feeling of hoarseness.
  • Feeling like something is caught in the esophagus or throat area.

In the more severe cases of GERD, symptoms may include:

  • Belching
  • Bloating
  • Blood in stool or vomit
  • Dysphagia the condition of having a narrowed esophagus, can lead to individuals feeling as though food has not gone down properly when eating or has become stuck in the throat
  • Frequent and long lasting occurrences of hiccups
  • Nausea
  • Unexplained loss of weight
  • Wheezing accompanied by a scratchy or sore throat

*Please contact your doctor should you experience symptoms of GERD or experience heartburn more than twice per week.

Causes

Hyperacidity occurs as a result of several different causes. The most common of these are ulcers in the lining of the stomach, GERD, cancer of the stomach, or a diet that is high in spicy foods.

Acid reflux, and the resulting heartburn, is typically caused by a condition of the lower esophageal sphincter (LES.) This sphincter is found in-between the esophagus and the stomach. The role of the LES is to prevent acid that is present in the stomach (due to normal digestive processes) from leaking into the esophagus.

The LES will regularly open during eating so that food can pass into the stomach area for digestion or to allow for belching as needed. When the LES becomes underactive or fails to provide the necessary seal due to poorly timed opening or improper closing, reflux can occur. Problems with the LES can occur due to overeating, which leads to an overfull stomach with too much food. Being overweight or pregnant also puts pressure on the stomach and can lead to the same problems.

Additionally, the LES can become relaxed, causing it to malfunction, as a result of diet or lifestyle.

Risk factors

Risk factors for acid reflux and heartburn are sometimes not a direct result of lifestyle and behavior, such as in the case of a medical condition. However, most of the time these risk factors can be controlled by making changes to ones habits or diet.

Some behaviors that are known to trigger occurrences of reflux and heartburn include:

  • Being overweight. Body fat can put pressure on the stomach which may lead to a malfunctioning LES (lower esophageal sphincter.)
  • Eating too much during meals, being overstuffed.
  • Lying down flat or bending over within 2 hours after eating.
  • Eating meals or snacks right before going to sleep.
  • Smoke can act as a stimulant in the production of gastric acid. Also, smoking may weaken the LES which causes it to relax.
  • Taking certain medications such as aspirin, ibuprofen, muscle relaxers or medication to treat blood pressure

Some of the foods and beverages that are known to increase the risks of having heartburn are:

  • Tomatoes and tomato-based products
  • Citrus fruit and juices (Examples: orange juice, lemons, lemonade, grapefruit juice, cranberry juice)
  • Garlic and onions
  • Chocolate
  • Dairy products (Examples: milk, ice cream, sour cream, yogurt)
  • Coffee (and other caffeinated products)
  • Some carbonated beverages
  • Alcohol (Examples: liquor, red wine, beer)
  • Peppermint
  • Dishes made with high levels of fats and oils or are fried
  • Dishes prepared using spicy ingredients

Having occasional heartburn is not usually a cause for concern. 30% of the U.S. population will experience infrequent moderate episodes that do not require medical attention. Frequent heartburn occurring more than twice a week for an extended period may indicate a serious medical condition or can develop into one.

Heartburn occurs daily for approximately 10% of the U.S. population. A doctor should be contacted if heartburn occurs over twice a week for a continuous two weeks or longer.

Prevention tips

1) Keep an eye on portion sizes. Eating until stuffed puts pressure on the stomach. A very large meal will stc6ay in the stomach fc6or longer and increc6ase the chances of reflux. Reduce the size of meal portions so that you are feeling satisfied after eating rather than full.

2) Take the time to eat slowly. Slowing down can keep you from overeating.

3) Don’t eat meals and snacks within two hours of going to sleep. Eating several hours before bedtime will allow your stomach to digest properly and empty prior to lying down. This will also give time for the acid produced during digestion to decrease again.

4) Know which foods trigger heartburn and avoid them. A food diary can help to track the foods that will cause heartburn. Staying away from these foods can reduce the occurrences of heartburn. Each person is different and some food items can be triggers for some people and not others.

5) Be careful when eating out. Stay away from foods with high fat content, a low fat option is always better. Also, restaurant portion sizes are typically very large. Decide in advance to take half the meal home to avoid overeating.

6) Lose weight. Symptoms of heartburn can be reduced by shedding some pounds, which reduces some of the pressure on the stomach.

7) Avoid tight fitting clothes. Clothing that is too tight around the stomach area may put pressure on the stomach and the LES (lower esophageal sphincter.)

8.) Quit smoking. Smoke can cause or worsen the symptoms of heartburn.

9) Don’t drink alcohol. Or just keep a watch on alcohol consumption. Some alcoholic beverages trigger heartburn more frequently (such as red wine.)

10) Do not exercise within two hours of eating a meal. A full stomach combined with the movement and strain of exercise can lead to acid reflux and heartburn.

11) Increase your water consumption. Keep the body hydrated and avoid carbonated and caffeinated beverages to assist the body with digestion.

Test and Diagnosis Considerations

Frequently occurring heartburn could indicate a medical problem and a doctor should be contacted. Doctors may run diagnostic tests to determine the nature of the heartburn or to see if it is a reflection of a more serious concern.

Upper Endoscopy Procedure where a thin and flexible tube called an endoscope is inserted into the throat. Doctor can then examine the upper lining of the gastrointestinal tract (includes the esophagus, stomach and part of the small intestine.)

This procedure can provide more accurate results than x-rays because it gets a much closer view of the lining. From an endoscopy, a doctor can diagnose inflammation in the gastrointestinal tract, ulcers, hernias, growths, obstructions, precancerous conditions or cancer.

Bernstein Test

Bernstein Test (or an acid perfusion test) Procedure where the doctor will attempt to reproduce symptoms related to heartburn in order to determine if acid from the stomach is the cause of the heart burn. A nasogastric (NG) tube will be inserted into the esophagus through the nose.

A solution similar to stomach acid will then be passed into the esophagus to determine if the heartburn sensation has been reproduced followed by a saline solution. From these tests, a doctor may be able to determine if the esophagus is irritated, if acid reflux is the cause of heartburn, or if additional testing will be necessary.

Esophageal Manometry Procedure

Esophageal Manometry Procedure performed to determine if the esophagus properly contracts. The doctor will pass a pressure-sensitive tube through the esophagus (through mouth or nose) and into the stomach. Pressure on the tube after swallowing can be measured to determine the effectiveness of the esophagus contractions. This is usually conducted prior to a surgery on the esophagus being considered.

PH Tests & Xrays

PH Test Procedure performed to measure the amount of the stomach acid present or backed up into the esophagus. A thin plastic tube will be inserted into the esophagus through the nose and is left in place for 24 hours. Regular activities should be continued for the day in order to get the most accurate acid measurements.

Barium X-Rays (or barium swallow) X-rays taken after ingestion of a liquid containing barium. The doctor can see the flow of the barium into the digestive tract to spot ulcers, hernias, or other abnormalities.

Treatment Options

There are many courses of action one may take to relieve the symptoms of hyperacidity and heartburn. Beyond simple prevent, there are home remedies, medicines, and surgeries that can help affected individuals.

Herbal & Home Remedies

Living enzymes in food are said to help with digestion and can help with or eliminate acid reflux. A diet high in organic, fresh, and raw fruits and vegetables will add living enzymes to the stomach and can lead to improvement of heartburn symptoms.
Herbal Heartburn Treatment
Some other remedies that may offer natural heartburn relief:

  • Ginger root can be added to teas
  • Anti-inflammatory herbs can help to repair tissue in esophagus that been damaged
  • Anti-anxiety herbs such as slippery elm root bark powder

Stress and anxiety are known to aggravate acid reflux and heartburn symptoms. Finding methods to deal with normal anxiety and stress naturally can help to lessen symptoms. Some examples of natural ways to reduce anxiety and stress include aromatherapy, massage, meditative relaxing techniques or gentle exercise.

Pharmaceutical Remedies

For many individuals with lesser to moderate symptoms of heartburn, a combined strategy of avoiding triggers and using over-the-counter medicines can be an effective means for controlling heartburn and acid reflux.

There are many over-the-counter medicines on the market that can neutralize stomach acid or otherwise reduce heartburn. Some of these include:

  • Foaming agents (such as Gaviscon) work to prevent reflux by coating the lining of the stomach
  • Antacids (such as Alka-Seltzer, Maalox, Rolaids, Riopan Pepto-Bismol, and Mylanta) can rapidly bring relief of symptoms by neutralizing the acid in the stomach
  • H2 Blockers (such as Tagamet HB, Zantac 75, Axid AR or Pepcid AC) will reduce the levels of acid being produced in the stomach

These medicines are easily accessible and affordable. However, there can be risks and side effects associated with long term use of these medications. Diarrhea, stomach cramping, headaches, nausea and constipation may occur with frequent use. Individuals taking antacids should ensure they are being taken according to instructions provided by their doctor or listed on the packaging.

Prescription Strength

When over-the-counter medicines are not providing relief, a doctor may prescribe medication for more severe cases. Those who experience very frequent occurrences of heartburn, experience hyperacidity, or individuals with gastroesophageal reflux disease (GERD) will benefit the most from the prescription medications that are taken once daily and work for 24 hours.

Proton pump inhibitors (such as Prilosec, Nexium, Protonix, and Prevacid) will reduce the amount of acid produced more effectively and for a more extended period of time than H2 blockers and also work to repair damage to the esophagus.

Prokinetics or Promotility agents (such as Reglan) can force the stomach to empty itself quicker, thus assisting the pressure on the LES and reducing acid reflux. They will stimulate stomach muscles to move food further along the gastrointestinal tract.

Side Effects

Side effects and risks associated with these types of prescription medications vary. Effects that should be reported to a doctor when taking proton pump inhibitors include confusion, tightness in the chest, fever, irregular heart beat and fatigue. High doses of prokinetics or promotility agents may reduce the absorption of other important medications and can cause effects such as drowsiness, diarrhea, restlessness, movement problems and issues with kidney functions in older adults.

Surgery

For some individuals, medications may not provide enough relief of symptoms. For these cases or where the symptoms seem to negatively interfere with ones life, individuals may undergo surgery that may assist in offering relief of GERD and heartburn symptoms. Doctors may also recommend surgery when the LES fails to work properly or when esophageal cancer has developed from chronic GERD. If not properly treated, long term cases of reflux can cause serious issues or complications.

Laparoscopic Surgery- A procedure which is minimally invasive and utilizes a thin instrument attached to a tiny video camera and light source. The video transmits images to a monitor and this helps to avoid the need for larger incisions. This procedure will create an artificial valve in the stomach. The top portions of the stomach will be wrapped around the LES through an incision in the abdomen or chest area using a lighted tube. The new valve can strengthen the LES and prevent future episodes of acid reflux.

Individuals who meet certain criteria would be considered the candidates most likely to benefit from this surgery.

  • No previous abdominal surgery
  • Most often experience symptoms when lying down
  • No history of bleeding disorder and no other major medical issues
  • Not pregnant

Benefits of Surgery

The benefits to this surgery include a short hospital stay and fast recovery/return to normal activities. There is less risk of infections and surgical complications due to the small incision that is used. This type of surgery is typically less expensive than more traditional and invasive surgeries. Surgery as treatment for GERD and heartburn symptoms would be considered a last resort.

Over 90% of those who undergo this surgery will be cured of their symptoms but there is no long term evidence to conclusively state that this cure will be permanent. Surgery as a method of treatment for reflux is debated in the medical world and many still believe medications are better long term solutions.

Those patients who are not a candidate for this type of laparoscopic surgery may require more invasive procedures to treat GERD. This may include laparotomy (which involves cutting open the abdomen) or thoracotomy (which involves cutting open the chest.)

Conditions

Frequent Urination

Frequent Urination Condition

Frequent urination simply means urinating more often than usual. Its a symptom rather than a condition. Most people empty their bladders between four and eight times a day; frequent urination is therefore defined as voiding urine more often than eight times a day with the implication that this increased rate is not strictly volitional.

Frequent urination does not always signify an underlying health problem.

You may be drinking too much fluid, or possibly you need to modify your food and beverage intake: alcohol, caffeinated beverages such as coffee and tea and even some foods such as celery, watermelon and parsley are natural diuretics increasing the amount of urine you would normally excrete.

Female Urinary System.

Underlying Problems

But frequent urination is often a sign of an underlying medical pathology, most often a urinary tract infection or cystitis (an inflammation of the bladder) that can affect either sex although it most common in women.

Frequent urination can also be the first symptom of diabetes, both type 1 and type 2, as the body mobilizes the urinary system to rid itself of excess glucose.

Frequent urination is linked to prostate problems in men and to pregnancy and pelvic inflammatory disease in women. The symptom is also a common side effect of obesity and abdominal radiation treatments.Frequent Urination Symptoms

Even when frequent urination is not connected to an underlying pathology, it can be a disruptive and embarrassing condition. When you have to go, you have to go no matter what else is happening around you.

When frequent urination forces major changes in lifestyle habits or is accompanied by fever, pain, nausea and vomiting, increased or decreased appetite, genital discharge or changes in the appearance of the urine itself, it’s time to consult a physician about the condition.

Alternative Names

There are several different conditions which are closely associated with frequent urination:

Urgent Urination, Urinary Urgency

A sudden, compelling need to urinate linked to a burning sensation or pain, often a sign of an underlying urinary tract infection.

Urge Incontinence, Urinary Incontinence, Overactive Bladder Syndrome

A sudden, irresistible need to urinate due to bladder spasms. Symptoms include urinary frequency, urinary urgency, and sometimes leaking urine before you can get to a toilet.

Stress Incontinence

Involuntary urination that occurs during an activity such as coughing, sneezing or laughing, generally caused by an underlying anatomic weakness to the bladder.

Nocturia

Frequent urination at night involving waking up several times to use the toilet.

Polyuria

The production of excessive volumes of urine for an adult, over 2.5 liters in 24 hours.

Depending on the underlying cause of your urinary frequency, you may experience some of these symptoms as well.

Physiology

Urination is the process by which urine is eliminated from the body, a function which in healthy humans is partly under voluntary control.

Cellular metabolism generates nitrogenous waste products that must be eliminated from the bloodstream. These wastes are filtered out of the bloodstream by the kidneys. There are two kidneys in the body, each made up of microscopic structures called nephrons that act as filtering units removing most of the water, salt and waste from the blood that passes through them.

The resulting liquid waste product called urine is transported through anatomic structures called ureters to the bladder where it is stored. The anatomical structure of the ureters and bladder do not allow urine to back up towards the kidneys under most circumstances.

Bladder Muscles

The bladder has two sets of muscles controlling its opening. Only the external sphincter is under voluntary control. Both the internal sphincter and the smooth muscle in the wall of the bladder are under the control of the parasympathetic nervous system. As your bladder fills with urine, the smooth muscle stretches by means of small contractile waves to accommodate the extra volume of urine. When urination occurs, the bladder’s outer layer of muscle (called the detrusor) contracts to help push out urine.

Urine is excreted from the bladder through the urethra, a process called urination. The average adult bladder can hold between 300 and 500 cc of urine. Urine is sterile when it is excreted from the body: it contains fluid, salts and waste products, but it is free of bacteria, viruses and other pathogenic organisms.

Causes of Frequent Urination

Overactive Bladder

Overactive bladder is a condition associated with a sudden, irresistible urge to urinate, resulting from involuntary contractions of the musculature of the bladder wall.

Overactive bladder is particularly common among middle-aged and older adults, and some medical experts estimate that one out of ever 11 adults in the United States suffers from some form of it. Untreated overactive bladder can lead to an increased incidence of urinary tract infections and skin infections from the corrosive effects of urine on the delicate skin of the urogenital area. But treatment success rates are high: with behavioral modification techniques and medication, 80% of people are able to bring their symptoms under control.

Overactive bladder can be brought on by abnormalities of the nervous system such as spinal cord injuries, multiple sclerosis, strokes, Parkinson’s disease and diabetic neuropathy; by urinary tract infections; and by blockages to the urinary system such as those caused by kidney stones or an enlarged prostate. But in many cases, there is no underlying pathogenic cause to overactive bladder.

Medical History

Medical history plays an important role in diagnosis: urinary frequency, urinary urgency, stress incontinence and urinating more than three times a night are all suggestive of overactive bladder. A pelvic exam for women (to rule out pelvic inflammatory disease) and a prostate exam for men (to check for enlargement) are generally indicated. Ultrasonic measurement of the post-void residual (the amount of urine left in the bladder after urination) can further help determine whether symptoms are due to muscle spasms or some other cause.

If underlying pathology is ruled out then treatment for overactive bladder focuses on:

Improving the Tone of the Surrounding Pelvic Muscles

Doing Kegel exercises (also called pelvic floor exercises) for five minutes, two to three times a day, can markedly decrease incontinence in both women and men. Occasionally Kegel exercises are used in conjunction with biofeedback and electrical stimulation of the floor of the pelvis.

Behavioral Modification

Behavioral techniques called bladder training can teach you to resist the urge to urinate, gradually increasing the interval between trips to the toilet.

Peeing in public.

Medications

Several medications that block the effects of the neurotransmitter acetylcholine have proven successful in the treatment of overactive bladder. They share common side effects including dry mouth, constipation, blurred vision, and in the elderly, confusion.

  • Oxybutynin (Ditropan): Oxybutynin suppresses spasms in the smooth muscles of the bladder wall. Additionally it relaxes the detrusor.
  • Tolterodine (Detrol, Detrol LA): Tolterodine suppresses spasms in the smooth muscles of the bladder wall. It does not cause the mouth to dry out as much as Oxybutynin.
  • Solifenacin (VESIcare). Similar to Tolterodine, but with a longer half-life.
  • Tricyclic antidepressants such as imipramine (Tofranil) and doxepin (Sinequan, Adapin) have also been used to treat overactive bladder with some success. Their mechanism of action is not clear.

Natural Treatments

If you are suffering from the symptoms of overactive bladder, there are a number of remedies you can try at home without seeking medical attention. Regulate your fluid intake. If you smoke, stop. Consider eliminating coffee, tea and other caffeinated beverages and foods: caffeine is a known diuretic.
treating frequent urination
Foods such as chocolate, spicy cuisines, alcohol and carbonated drinks can also irritate the bladder. If you are even a few pounds overweight, consider going on a diet: middle-aged people tend to put on weight in their abdomen, and all that extra avoirdupois exerts extra pressure on your bladder.

Constipation, similarly, also exerts extra pressure on your bladder so consider increasing the amount of fiber in your diet if you suffer from it.

Some naturopathic doctors believe that overactive bladder is linked to food sensitivities, particularly to wheat and dairy products.

These foods, it’s speculated, cause a systemic inflammation that manifests, among other things, as an inflamed bladder. By cutting out one food group for a period of time and observing how your symptoms respond, you can pinpoint the dietary culprit.

Mineral Supplements

A number of botanicals and mineral supplements have also been used to treat overactive bladder with some success.

Pumpkin

Native Americans have used pumpkin seeds for centuries to improve bladder and prostate health. Pumpkin is also one of the few natural remedies to be tested in clinical trials: in one six-week study of postmenopausal women suffering from overactive bladder, almost 60% of participants showed marked improvement.

Magnesium

Clinical trials have also proven the efficacy of magnesium, particularly among patients suffering from Parkinson’s disease. It thought to control smooth muscle spasms.

Saw Palmetto

Palmetto is commonly used throughout Europe to treat the symptoms of benign enlarged prostate. Its precise mechanism of action is unclear but it has anti-inflammatory properties and is known to reduce the activity of enzymes linked to prostate problems. Clinical studies have proved that it reduces urinary frequency. But palmetto has some mild estrogenic effects; for that reason, women who are pregnant, breastfeeding, taking birth control pills or undergoing hormone therapy should avoid it.

Stress Incontinence

Stress incontinence is the involuntary loss of urine due to a sudden pressure on the abdominal muscles secondary to physical activities like coughing, sneezing or laughing.

While its symptoms and many non-invasive treatments are similar to those for overactive bladder, its underlying cause is quite different: it due to a weakening of the pelvic musculature which in men can occur following a prostatectomy and among women is a common aftermath to childbirth among women (exacerbated when estrogen levels decrease in the week before menstruation or following menopause.)

In addition to the treatments described under overactive bladder above, one non-surgical treatment that sometimes used for women suffering from stress incontinence is the insertion of a small ring-shaped medical device called a pessary into the vagina. The pessary reduces stress incontinence by compressing the urethra against the symphysis pubis bone. If a woman uses this treatment option, she must be carefully monitored by her physician to reduce the chance of contracting a vaginal or urinary tract infection.

Surgical treatment is only considered if other non-invasive treatments have failed and the exact anatomical site of the pelvic muscle weakness is known.

Nocturia

Nocturia is the medical term for frequent urination at night. It can be a symptomatic of a systemic disease process such as a kidney or bladder infection, diabetes or sleep apnea; in men, it is often the first sign of prostate enlargement. But even when its causes are relatively benign, nocturia can still be a difficult condition to live with because it interferes with sleep.

Interventions to try at home include minimizing all fluid intake but particularly caffeine and alcohol for at least three hours before bedtime, taking medications that have a diuretic effect earlier in the day, and avoiding strenuous exercise and potentially stressful interactions before sleep. You should see your physician if nighttime urination is accompanied by fever, pain or discomfort, or if your urinary frequency is not affected at all when you cut down on fluids before bedtime.

Medical History and Testing

Since nocturia is frequently a symptom of an underlying systemic pathology, when you visit your physician, he or she will try to rule these out by taking a thorough patient history, performing a physical exam, and ordering diagnostic tests such as urinalysis, urine culture, blood sugar and BUN/creatinine clearance.

Nocturia can be a symptom of benign prostate enlargement, urinary tract infection, kidney failure, congestive heart failure, obstructive sleep apnea or diabetes.

Urinary Tract Infections (UTI)

Urinary tract infections are the second most common type of infection, resulting in 8.3 million visits to doctors offices every year. UTIs are named differently according to the primary site of infection:

  • Urethritis is an infection of the urethra
  • Cystitis is an infection of the bladder
  • Pyelonephritis is a kidney infection

In addition to urinary symptoms like urinary frequency and urinary urgency, UTI symptoms can include low-grade fever, abdominal or back pain, and urine that appears cloudy and has an unusual or foul odor. With more serious infections that spread to the kidneys, symptoms may include a fever over 101 degrees Fahrenheit with chills and night sweats, nausea and vomiting and more severe pain in the abdomen or lower back or referred to the flank.

In a significant number of cases, UTIs are asymptomatic. Indeed among the elderly for whom UTIs are a huge concern, the only symptoms may be confusion, combativeness or other changes in mentation.

UTIs occur when bacteria contaminate the urethra opening and begin to multiply. The most common contaminant is Escherichia coli (E. coli), a bacteria which typically lives in the intestines and the most common source of infection in active individuals is fecal contamination following bowel movements. But any abnormality in the urinary tract that obstructs the free flow of urine a kidney stone, for example, or an external catheter can set the stage for infection.

Higher Risk Categories

Women are more prone to UTIs than men, possibly because their urethras are shorter and closer to the anus. Medical experts estimate that half of all women will experience a UTI at least once in their lifetime, and most of them more than once. Factors that increase a woman™s susceptibility to UTIs include sexual activity (because intercourse can irritate the urethra,) use of the diaphragm as a birth control device, and aging since the decrease in estrogen following menopause leads to more fragile urogenital tissues.

If the UTI involves mild discomfort but no fever, you can try to manage it at home. Your goal will be to flush the offending microorganisms by drinking lots and lots of water. Avoid drinking caffeinated beverages such as coffee and tea, alcohol and carbonated beverages as these will irritate your bladder. Since an ounce of prevention is worth a pound of cure, for the future remember to wipe from front to back after a bowel movement (rather than the other way around), to urinate as soon as possible after sexual intercourse and (for women) to avoid potentially irritating feminine hygiene products.

Cranberry Juice

For more than a century, cranberry juice has been used as a natural remedy for UTIs. Cranberries contain substances called proanthocyanins which seem to prevent bacteria from sticking to the walls of the urinary tract. Don’t use the highly sweetened cranberry juice you find in supermarkets for this purpose. Instead use unsweetened cranberry juice or cranberry extract tablets available from health food stores.

If you are running even a low-grade fever or your UTI is causing you significant discomfort, then you should opt to see a physician for treatment.

Definitive diagnosis will be made on the basis of a urinalysis done on a clean, mid-stream catch specimen of urine. Blood, pus and/or bacteria will be present in a urinalysis that’s positive for a UTI. Occasionally a urine culture may also be ordered to test for specific strains of bacterial infection. Other tests your physician may order if he or she thinks your infection may be more serious include blood cultures and a CBC.

Treatment Options

The first line of treatment for a simple UTI is antibiotics. Commonly used antibiotics include Amoxicillin (Amoxil, Trimox), Ciprofloxacin (Cipro), and Sulfamethoxazole-trimethoprim (Bactrim). Symptoms often respond to treatment within 24 hours, but it is important to complete the antibiotic regimen even if symptoms have disappeared otherwise the implicated bacteria may develop a resistance to that antibiotic.

Your doctor may also prescribe medication called Phenazopyridine hydrochloride (Pyridium) to control the burning sensation you experience upon urination. One side effect of Pyridium is that it turns your urine bright blue!

If your UTI has made you extremely sick or you are incapacitated in some way that makes your doctor think you will be unable to adhere to the antibiotic protocol (as sometimes happens with elderly patients), your doctor may recommend hospitalization so that antibiotics and fluids can be administered intravenously

References:

Vitamins

Vitamin B6

Vitamin B6

Pyridoxine, Pyridoxal Phosphate, Pyridoxamine

Overview

Vitamin B6 is a part of the vitamin B complex group. The vitamin is water-soluble and is sometimes referred to as Pyridoxine. This vitamin aids in the metabolism of amino acids and the production of glucose from glycogen.

Though many of the vitamin B group members have properties that work against cancer, vitamin B6 has no known anti-cancer effects associated.
vitamin b6 uses
More studies must be conducted to conclude its effects. Some unofficial studies indicate vitamin B6 effectiveness in preventing colon cancer in healthy patients. However, more studies are necessary. Some experts indicate that vitamin B6 have been effective in treating patients with prostate cancer.

Recommended Daily Allowances (RDA)

Experts recommend consuming foods that allow individuals to meet their daily allowance without a supplement. Most people can meet their daily requirement for vitamin B6 without a supplement. Those who cannot meet the daily requirements should consider a supplement.

Experts recommend taking the vitamin after a meal and with copious amounts of water. Children who need a vitamin B6 supplement should consult with a physician prior to consumption.

The daily allowances of vitamin B6 vary by age groups. Experts recommend increasing vitamin B6 dosage as the person ages:

  • Males: 14 to 18 years: 1.3 mg Average
  • Females: 14 to 18 years: 1.2 mg Average
  • 19 to 50 years: 1.3 mg
  • Males: 51 years and older: 1.7 mg
  • Females: 51 years and older: 1.5 mg
  • Pregnant females: 1.9 mg
  • Breastfeeding females: 2.0 mg
  • Newborns: 0 to 6 months: 0.1 mg
  • Infants: 7 months to 1 year: 0.3 mg
  • Children: 1 to 3 years: 0.5 mg
  • Children: 4 to 8 years: 0.6 mg
  • Children: 9 to 13 years: 1 mg

To prevent heart disease or lower homocysteine levels, patients should consume 3.0 mg per day of vitamin B6. Physicians have in the past prescribed more to treat certain conditions. However, vitamin B6 should not be consumed in doses above 100 mg per day without a doctor’s supervision.

Sources of Vitamin B6

As mentioned earlier, experts recommend receiving the daily recommended allowance of food from natural food sources. Some of these sources may include the following foods:

  • Chicken
  • Tuna
  • Turkey
  • Salmon
  • Shrimp
  • Beef Liver
  • Lentils
  • Beans
  • Sunflower Seeds
  • Carrots
  • Spinach
  • Milk
  • Cheese
  • Brown Rice
  • Bran
  • Wheat Germ
  • Whole-Grain Flour

For those who cannot meet the daily allowances, vitamin B6 can be found in supplements, such as multivitamins, and B complex vitamins. Adult vitamins may be found in the form of tablets, softgels and lozenges. Children’s supplements are often found in chewable tablets or liquid drops. Those seeking vitamin B6 supplements should also check for the names pyridoxamine, pyridoxal, pyridoxine hydrochloride, and pyridoxal-5-phosphate. Each name represents the vitamin B6 supplement.

History of Vitamin B6

Vitamin B6 was first discovered during a study in the 1930s. The study originated from scientists who were studying nutrition in rats. Paul Gyorgy, a Hungarian physician, first discovered vitamin B6 when he recognized that he could cure skin disease in rats with vitamin B6. Another scientist, Lepkovsky, isolated vitamin B6 from rice bran.

The structure of pyridoxine was demonstrated by Harris and Folkers in 1939. By 1945, scientist, Snell, was able to prove two separate structures of vitamin B6 existed. One of the structures was referred to as pyridoxal and the other pyridoxamine. After this discovery, vitamin B6 was referred to as pyridoxine to indicate its relationship to the structure pyridine. Each of the three forms of vitamin B6 paid a large role in the essential enzyme production within the body.

The enzymes promoted by vitamin B6 involve several amino acids. Scientists have documented over 140 activities related to the presence of vitamin B6 in the body.

Health Benefits

Several health benefits have been documented by scientists as it relates to vitamin B6. Some of the most common health benefits are listed below:

  • Scientists have long speculated that vitamin B6 played a significant role in the treatment for Pre-Menstrual Syndrome (PMS), Pre-Menstrual Dysphoric Disorder (PMDD), and clinical depression.
  • Some scientists have cited that vitamin B6 plays a significant role in the treatment for schizophrenia and autism.
  • Studies have shown that vitamin B6 have increased the vividness of dreams and the ability to recall dreams. Scientists suspect that dream vividness is due in part to the conversion process of tryptophan to serotonin. Vitamin B6 is a component in this process.
  • Some studies show that the consumption of vitamin B6 could reduce the risk of Parkinson’s disease by 50 percent. One such study was conducted in the Netherlands. However, the analysis showed that only smokers showed a decrease in the risk.
  • Vitamin B6 or pyridoxine plays a significant role in heart disease prevention. Homocysteine levels rise when there is a pyridoxine deficiency. Studies have shown that elevated homocysteine levels may damage blood vessel linings and promote blood clots. When the body attempts to heal the blood vessel linings, it makes the person more vulnerable for plaque buildup and blood clots. Vitamin B6 prevents buildup and reduces the risk of heart attack.
  • Pyridoxine or vitamin B6 lowers cholesterol levels and blood pressure. This keeps the blood platelets from coagulating to form a clot.
  • Physicians often recommend a vitamin B6 supplement combined with magnesium to combat autism. This is a popular remedy in alternative medicine for this disease. Children develop autism before the age of three. This disorder affects the nervous system. Children suffering from the disorder often have difficulty with social interaction and communication.
  • Some scientists indicate that vitamin B6 combined with magnesium can also alleviate the symptoms associated with attention deficit disorder (ADD). Studies have shown that the combination can improve hyperactivity, aggressiveness, and attention span in a classroom or work setting.
  • Individuals who have a vitamin B6 deficiency may also experience sensitivity to monosodium glutamate (MSG). MSG is a popular flavor enhancer found in many Asian dishes. Some people report nausea, dizziness, vomiting, headaches, pain or tingling of upper extremities after consuming the Asian food containing MSG. Studies show an improvement in individuals who possessed a deficiency prior to consuming MSG.
  • Individuals with a deficiency in vitamin B6 may be more susceptible to developing carpal tunnel syndrome. This may occur if the person is on minimally deficient in vitamin B6. Individuals who suffer from carpal tunnel syndrome may experience pain and tingling in the wrists after typing repetitively or other repetitive hand motion. Two studies have shown that vitamin B6 has been beneficial in treating carpal tunnel syndrome in patients who do not have significant trauma.
  • Vitamin B6 has been recommended by physicians and scientists for relieving premenstrual syndrome (PMS). However, the data is inconclusive as to which symptoms are relieved by the intake of Vitamin B6. Some studies show that females who consume vitamin B6 have fewer symptoms of bloating, acne flares, and breast pain. Studies show strong evidence leaning towards the effects of vitamin B6 in acne flares that begin before and during a women’s menstrual cycle. The acne flares are a result of a hormone imbalance that occurs before and during a woman’s menstrual cycle. Approximately ten days before a woman’s menstrual cycle, vitamin B6 should be consumed to prevent acne break outs. The vitamin is thought to be effective because it regulates hormones and prostaglandin.
  • Some experts cite that a deficiency of vitamin B6 may also lead to depression. Vitamin B6 or pyridoxine helps to produce serotonin and other neurotransmitters. After a vitamin B6 supplement, patients cite that their mood and their memory improve.
  • Individuals suffering from morning sickness have cited that consumption of vitamin B6 alleviated some of the symptoms associated with this ailment. Experts speculate that this may be in part due to the fact that vitamin B6 may act as a diuretic.
  • Other studies indicate that vitamin B6 may be effective in alleviating the effects of an alcoholic hangover as well. This is also due to the diuretic nature of vitamin B6. More studies should be conducted to prove this finding conclusively.
  • Some experts suggest that vitamin B6 or pyridoxamine has been effective in treating diabetic nephropathy. Further studies should be done to prove this finding conclusively.
  • Studies show that moderate intake of vitamin B6 may decrease the risk of colon cancer by half. More studies are necessary to prove the finding conclusively.

Ailments from Vitamin B6 Deficiencies

The benefits from vitamin B6 consumption are plentiful. Conversely, the lack of vitamin B6 may cause some undesirable conditions. Some of the most common deficiencies are listed below:

  • Atrophic glossitis
  • This condition is referred to as smooth tongue. Experts have suggested that a tender or painful tongue may be the result of a vitamin B6 deficiency.

  • Angular cheilitis
  • Angular cheilitis describes a lesion at the corner of the mouth that is usually characterized by cracks or splits. The lesion may also be inflamed. Scientists have come to believe that vitamin B6 deficiency may play a role in the development of this condition.

  • Intertrigo
  • Intertrigo describes the rash or inflammation that occurs where the body folds. Areas such as, under the arms, under the breast and other places are affected. Vitamin B6 deficiencies may lead to this condition. More research is needed to prove this conclusively.

  • Conjunctivitis
  • Conjunctivitis describes the inflammation of the eye. The condition often occurs because of an allergic reaction or an infection. The condition may be viral, but it is sometimes bacterial. Vitamin B6 deficiencies may also be the cause of this condition as well.

  • Seborrehoeic dermatitis
  • Seborrhoeic dermatitis may also be known as Seborreheic eczema. The condition affects sebum rich areas of the body, such as scalp, face and torso. The skin becomes scaly, flaky, itchy, and red as a result. These symptoms are characteristic of vitamin B6 deficiencies.

  • Somnolence
  • Somnolence is a strong desire for sleep for long periods of time. This chronic condition may be a result of a vitamin B6 deficiency.

  • Confusion
  • When a vitamin B6 deficiency occurs in the body, individuals have reported states of confusion or loss of orientation. The person may forget their personal identity or be unable to locate themselves properly within the world.

  • Neuropathy
  • Some of the most common neuropathic disorders are associated with diabetes mellitus. This occurs when there is an injury to the small blood vessels that supply nutrients to the nerves. Vitamin B6 deficiencies may be the cause of some of these common neuropathic disorders.

  • Rheumatoid arthritis
  • Individuals with rheumatoid arthritis often have low levels of vitamin B6. Some studies indicate that people with rheumatoid arthritis may need to consume more vitamin B6 than healthy people. This is due chronic inflammation problems associated with rheumatoid arthritis. Individuals suffering with rheumatoid arthritis should consult their doctor before taking any supplements.

  • Heart disease
  • Individuals who have deficiencies of vitamin B6 in their diets are at greater risk for heart disease. Individuals with high homocysteine levels associated with low levels of vitamin B6 may have damaged blood vessels and increased chances of blood clot formation.

  • Depression
  • Vitamin B6 deficiencies are often associated with depression. Serotonin levels affect a person’s mood. Experts suggest that vitamin B6 plays a role in the production of serotonin. Therefore, increased vitamin B6 intake may improve depression. More research is being conducted to determine its true benefit.

  • Carpel tunnel syndrome
  • Experts have found that deficiencies in vitamin B6 may contribute to the symptoms of carpal tunnel syndrome. More studies should be performed to prove this finding conclusively.

  • Pre-menstrual syndrome
  • Vitamin B6 deficiencies may be a factor in symptoms associated with PMS. Many of the studies conducted to prove that vitamin B6 deficiencies played a role PMS were not designed properly. Therefore, more research must be conducted to prove this finding conclusively. However, many female patients have remarked that vitamin B6 supplements have alleviated some of the symptoms and improved their moods. Consult a physician before beginning a vitamin B6 regimen. Improvements may take up to 3 months.

  • Morning sickness
  • Several studies have been conducted to prove that vitamin B6 deficiencies may cause morning sickness. Pregnant women who consumed 30 mg of vitamin B6 daily found that the effects of morning sickness decreased. Pregnant women should consult with a physician before taking vitamin B6 supplements.

  • Parkinson’s disease
  • Some experts suggest that daily consumption of vitamin B6 may reduce the risk of Parkinson’s disease. This is thought to be true since the vitamin improves neurological functions. More studies are needed before this finding is conclusive.

Vitamin B6 deficiency is uncommon in individuals as a solitary deficiency. The deficiency is usually accompanied by another deficiency, such as another vitamin in the B complex. The elderly, most commonly, experience a vitamin B6 deficiency. Alcoholics may also experience a vitamin B6 deficiency. Renal patients undergoing dialysis may also experience vitamin B6 deficiencies.
vitamin b6 deficiency
Patients consuming anticonvulsants or corticosteriods may experience a vitamin B6 deficiency, as well.

Severe vitamin B6 deficiencies may lead to damage to the nervous system and also to the skin. Less severe deficiencies due to an impaired tryptophan-niacin conversion may manifest as lesions to the skin.

Physicians can detect this impairment by testing the urine for xanthurenic acid. Vitamin B6 deficiencies may also occur from an impaired process of “transsulfuration of methionine to cysteine.”

Precautions when Taking Vitamin B6

Patients who are taking any of the following medications should consult a physician prior to starting a vitamin B6 regimen:

  • Cycloserine or Seromycin: This medication is used to treat patients afflicted with tuberculosis.
  • Hydralazine or Apresoline: This medication is used to treat patients with high blood pressure.
  • Isoniazid: This medication is used to treat patients with tuberculosis.
  • Penicillamine: This medication is used to treat rheumatoid arthritis.
  • Theophylline or TheoDur: This medication is used to treat asthma.

Most of these medications may require a supplement because the medications deplete the system of vitamin B6. However, it is also always recommended to consult a physician to avoid complications or problems associated with vitamins.

Drug Interactions

Antibiotics: Vitamin B6 vitamins have been known to interfere with the absorption of the antibiotic tetracycline. The timing of the vitamins and antibiotics should be spaced out in order to avoid unpleasant interactions.

Antidepressant Medications: Experts recommend taking vitamin B6 to boost the effectiveness of antidepressants. Some antidepressants that benefit from vitamin B6 are as follows:

  • Nortriptyline or Pamelor
  • Amitriptyline or Elavil
  • Desipramine or Norpramin
  • Imipramine or Tofranil
  • Monoamine Oxidase Inhibitors (MAOIs), such as Phenelzine (Nardil) or tranylcypromine (Parnate)

Chemotherapy drugs: Vitamin B6 may reduce some of the side effects associated with chemotherapy drugs, such as 5-fluorouracil and doxorubicin. Consult a physician before taking a vitamin B6 supplement.

Erythropoietin (EPO): Erythropoitin therapy may deplete vitamin B6 levels present in the body. Therefore, some people may need a supplement in order to replenish vitamin deficiency.

Levodopa: This medication is used to treat Parkinson’s disease. Experts suggest that vitamin B6 reduces the effectiveness of levodopa. A physician should determine the dosage of vitamin B6 that is required to avoid interaction with the drug. A physician should closely monitor the consumption of both drugs in combination.

Phenytion or Dilantin: Patients who take phenytoin for seizures may notice that the drug is slightly less effective if taken with vitamin B6. Patients should consult a physician prior to taking the drugs in conjunction.

Role in Biological Process

Vitamin B6 or pyridoxal phosphate is involved in several biological processes. Pyridoxal phosphate is involved in neurotransmitter synthesis, histamine synthesis, macronutrient metabolism, gene expression and hemoglobin synthesis. This metabolically active form of vitamin B6 acts as a coenzyme to help facilitate transamination, racemization, decarboxylation, elimination, replacement, and beta-group interconversion reaction. Vitamin B6 is metabolized in the liver.

Amino Acid Metabolism

Pyridoxal phosphate (PLP) plays a significant role in the metabolism of amino acids. This vitamin assists two enzymes as methionine is converted to cysteine via two separate reactions. When there is a vitamin B6 deficiency, there is decreased activity related to these enzymes. Pyridoxal phosphate is also responsible for assisting the enzymes found in the metabolism of selenomethionine to selenohomocysteine.

Selenohomocysteine is converted to hydrogen selenide. Vitamin B6 is also involved in the process of converting tryptophan to niacin. The conversion process will be impaired if vitamin B6 status is low. Vitamin B6 is also responsible for the conversion of the following amino acids:

  • Tryptophan to Serotonin
  • Histindine to Histamine
  • Glutamate to GABA (gamma-aminobutyric acid)
  • Dihydroxyphenylalanine to Dopamine

Gluconeogenesis

Pyridoxal phosphate is necessary for the gluconeogenesis process. The vitamin catalyzes transamination reactions. Vitamin B6 also acts as a coenzyme in the glycognenolysis process. The coenzyme is necessary for glycogen phosphorylase.

Lipid Metabolism

Vitamin B6 plays an important role in the biosynthesis of sphingolipids. This process is dependent upon vitamin B6 because one of the enzymes, S1P Lyase needs the vitamin to complete the process.

In most processes, vitamin B6 assumes the role of a coenzyme to other enzymes in the body in the metabolism process. Vitamin B6 is found in the following processes:

  • Gene Expression
  • Neurotransmitter Synthesis
  • Histamine Synthesis
  • Amino acid, lipid and glucose metabolism
  • Hemoglobin synthesis and function

Gene Expression

This process is responsible for transforming homocysteine into cysteine. The interim process involves changing cistation into cysteine. Pyridoxal phosphate plays a role in the gene expression process by increasing or decreasing the expression of genes present. A deficiency of vitamin B6 will lead to an increased expression of albumin mRNA.

Neurotransmitter Synthesis

Pyridoxal phosphate dependent enzymes are responsible for the biosynthesis of several neurotransmitters. The neurotransmitters include the following:

  • Serotonin
  • Epinephrine
  • Norpinephrine
  • Gamma-aminobutyric Acid

Histamine Synthesis

Pyridoxal phosphate or vitamin B6 is often involved in the metabolism of histamine.

Hemoglobin Synthesis and Function

The synthesis of hemoglobin is facilitated by pyridoxal phosphate. Vitamin B6 can bind on two sites present on hemoglobin. This process facilitates the binding of oxygen to hemoglobin.